Lupeol及其衍生／修饰物H2抗肝细胞肝癌作用及其机制的初步研究.pdfVIP

282 刘 芬 ，等 Luoeol及其衙生 ／修饰物 112抗肝细胞肝癌作用及其机制的初步研究 16] JiangK，HeB，LaiL，etalCyclosporineA inhibimbreastca… cellgrowthbydownregulatingtheexpressionofpyruvatekinase subtypeM2[J]lntJMolNed，2012，30(2)：302 308 ] lqbalMA，BamezaiRN Resveranolinhibitscancercellmetabo lism bydownregulatingpymvatekinaseM2viainhibitionof… maliantmgetofrapamycin[J]PLc~SOne，2012，7(5)：e36764 18] ChenJ，XieJ，JiangZ，etalShikoninanditsanalogsinhibitcanc ercellglyeolysisbytargetingm… pyruvatekinase M2[J]On 委一≤娶 洲 cogene20^ 30(42)：4292 4306 (编校 ：徐萌) … 量_～ 恤～_耋 ～ Lupeol及m其衍一生／修饰m物一H卜2抗肝细胞肝癌作用及其机制的初步研究 垂 刘 芬 ，何 艳 ，李云森 ，朱永明。，刘海燕 Anti—hepatocellularcarcinomaeffectoflupeolandilsmodifiedcompoundH2andthe mechanisms LiuFen ，HeYan ，LiYunsen ，ZhuYongming ，LiuHaiyan OncologyInstitute，TheFourthPeople~Ho~ital。}Wuxi，diangsuWuxi214062，China|_Laboratory。}Cellularand酣0kc越 Tumor1m mwu)logy，InstituteofBiologyand MedicalSciences，Soochaw University，．1ia~suSuzhou215123，China；SchoolofPharmacy，Medical College SoochOWUniversity．JiangsuS ^0M215123．C ina． 【Abstract】 Objective：Toinvestigatetheanti—hepatocellulareareinonlaeffectoflupeolanditsmodifiedeolll— pound，H2，andthelneehanislnsM ethods：Thestructureoflupeolwasmodified MqT assaymodifiedcompound，142 Flow cytomett7 analysiswasusedtodetecttheapoptosisinducedbylupeol／H2 Westernblotanalysiswasusedtode— tecttheexpressionlevelofcleaved—PAR