Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid：DI-SPME-LC-MS analysis.pdfVIP

JournalofPharmaceuticalAnalysis2014；4(1)：6-13 ContentstistsavailableatScienceDirect JournalofPh~ aceuticalAnalysis www．elsevier．com／locate／jpa www ．sciencedirect．corn 0RIGINALARTICLE M etabolicprofiling0fplasmafrom cardiacsurgical oat·i●ent·sconcurrent-Ily an1m i●ni■st·ereOlwi●th·l tJraneXam l●C acid：DI-·SPM E-LC-M Sanalysis BarbaraBojkoa，MarcinWa,sowiczb，JanuszPawliszyna，术 aDepartmentofChemistry，UniversityofWaterloo，200UniversityAvenueWest,Waterloo，Ontario，CanadaN2L3G1 DepartmentofAnesthesia，TorontoGeneralHospiatl,Toronto，Ontario，CanadaM5G2C4 Received31October2012；accepted14March2013 Availableonline 11April2013 KEYW 0RDS Abstract A metabolicprofileofplasmasamplesfrom patientsundergoingheartsurgerywiththeuse ofcardiopulmonarybypass (CPB)andconcurrentadministrationoftranexami cacidwasdetermined． M etabolomics； Heartsurgery； Directimmersionsolidphasemicroextraction(DI—SPME)，anewsamplingandsamplepreparationtool Cardiopulmonarybypass formetabolomics，wasusedinhtisstudyofrthefirsttimetoinvestigateclinicalsamples．Theresults Tranexamicacid； showedalterationofdiversecompoundsinvolvedindifferentbiochemicalpathways．Themostsignificant Directimmersionsolid contributioninchangesinducedbysurgery andappliedpharmacotherapywasnoticedinmetabolicprofile phasemicroextraction； Of1ysOphOsphOlipids，triacylglycerols，mediatorsofplateletaggregation，and linoleicacidmetabolites． LC，MS Twocasesofindividualresponsetotreatmentwerealsoreported． ◎ 2013Xi’anJiaotongUniversity．ProductionandhostingbyElsevierB．V．Allrightsreserved． 1．