nduced pluripotent stem cell （iPSCs） and their application n immunotherapy.pdfVIP

CellularMolecularImmunology(2014)11．17-24 @2014CSIandUSTCAllrightsreserved1672—7681／14$3200 www．nature．com／cm REVIEW Inducedpluripotentstemcell(iPSCs)andtheirapplication inimmunotherapy Zhengping]iang,YanmeiHanandXuetaoCao Theever-improvingtechnologytogenerateinducedpluripotentstem cells(iPSCs)hasincreasedtheirpotentialuseas novelcandidatesfordiseasemodeling，drugscreening，regenerativemedicineandeelltherapy．1ndeed。iPSCsoffer extensivecapacityforself-renewalwithouttheethicaIconcernsfacedbyembryonicstemcells(ESCs)．Withrespectto potentialapplicationsintheimmunesystem．manystudiesprovideevidencetosupportthatthereareexclusive advantagestousingiPSCsoverothersystems．Bothhematopoieticstem cellsandseveraItypesofmatureimmunecells havesuccessfullybeenreprogrammedtoiPSCsandv／ceversa．pavingapathtowardourabilitytoeffectivelymodeI patient-specificdiseasesandprovidepotentiallyalternativecelIsourcesfortransfusionmedicine．Despitethese potentialadvances。someIimitationsregardingtheuseofiPSCsintheclinicstillremain，includingtheimmunogenicityof iPSCsandtheirderivatives。whichiscurrentlyunderdebateinthefield。lnthisreview，wemainlyfocusondiscussingthe recentprogressbeingmadeinthelatestdi仟erentiationmethodsandclinicaIimplicationsofiPSCswithrespecttothe immunesystem．Additionally。currentissuesregardingtheclinicaIapplicationofiPSCsareaddressed。especially thecontroversysurroundingimmunogenicity，alongwithvariousotherperspectives． CellularMolecu／a厂，mmunology(2014)11．17—24；doi：10．1038／cmj．2013．62；publishedonIiBe16December2013 Keywords：differentiation；hematopoieticcell；immun0genicjty；immun0therapy；inducedpluripotentstem cells INTR0DUCT10N showed thatthePluripotencyofiPSCswascomparableto Stem cellshaveu111imitedself-renewalcapacityandcan