芍药甘草汤的精制分离 3.docVIP

目 录 1. 设计任书····················································03 2. 设计概述····················································04 2.1处方···················································04 2.2 用法··················································04 2.3功能主治·············································04 2.4药效物质成分类型、性质及药理作用·········05 3、常用精制技术简介······································06 3.1 常用精制分离方法·································06 3.2简析···················································0 4、课程实验···················································08 4.1 实验目的·············································08 4.2仪器与试剂···········································08 4.3实验内容··············································08 4.4检测····················································09 4.5实验数据及分析·····································10 5、工艺路线设计··············································1 5.1 处方····················································1 5.2制备工艺···············································1 5.3工艺流程及工艺说明································1 5.4提取物生产过程数据表·····························1 6、 结束语·······················································1 7、参考文献······················································1 一、设计任务书 1.1设计题目 芍甘汤提取、精制工艺设计 水提醇沉 1.2设计条件 芍甘复方颗粒剂提取物 1.3设计内容与要求 （1）确定提取工艺及参数； （2）确定精制分离工艺及参数； （3）提取物得率、成分含量以及相对密度； （5）编写设计说明书； 1.4设计成果 （1）设计说明书一份 包括概述（简要说明所设计的复方中药效物质成分类型、性质及药理作用等）；常用精制分离技术简述（主要为高速离心、醇沉、大孔树脂吸附以及超滤） 课程实验（不同精制方法的效果及比较）；工艺线路的设计（从最终制剂的剂型、工艺合理性以及生产成本等方面考虑）。 （2）芍甘汤提取精制工艺流程图； 1.5设计时间 设计时间为2周，从2013年5月12日至2013年5月23日。 二、设计概述 2.1处方组成 甘草12g 芍药12g 2.2用法 取上述2味，加600mL水煎煮至300mL，取液去渣，温服。 2.3功能主治 本方主治津液受损，阴血不足，筋脉失濡所致诸证。由芍药和甘草组成；方中芍药酸寒，养血敛阴，柔肝止痛；甘草甘温，健脾益气，缓急止痛。二药相伍，酸甘化阴，调和肝脾，有柔筋止痛之效。 其中芍药对疼痛中枢和脊髓性反射弓的兴奋有镇静作用，故能治疗中枢性或末梢性的筋系挛急，以及因挛急而引起的疼痛。芍药、甘草中的成分有镇静、镇痛、解热、抗炎、松弛平滑肌的作用，二药合用后，这些作用确能显著增强。 2.4中药药效物质成分类型、性质及药理作用 甘草 甘草的主要成分是甘草皂苷和甘草苷，甘草苷属于黄酮类成分；甘草皂苷属于三萜类成分。甘草皂苷又称甘草酸，由于有甜味，又称甘草甜素。 由冰乙酸中结晶出的甘草皂苷为无色柱状结晶，易溶于热稀乙醇，几乎不溶于无水乙醇或乙醚。其水溶液有微弱的起泡性及溶血性。甘草皂苷常以钾盐或钙盐形式存在于