医学影像学总论(2016版进修)幻灯片.ppt

After effective treatment, ADC value increased(less restricted diffusion) Changes in ADC value occurring earlier than variations in tumor size b=600sec/cm3 The changes in ADC values after treatment Radiotherapy / chemotherapy / ablation induced ADC value increase（3-7d） variation in tumor size Transient decrease after 24-48h treatment acellular edema Finally decreased - regeneration / fibrosis / remodeling perfusion Specificity of liver-specific contrast agent？ * Myung-Won You, et al. Recent advances in the imaging of hepatocellular carcinoma. Clinical and Molecular Hepatology 2015;21:95-103 N Engl J Med 2012;366:883-92 Tumor heterogeneity * 5mm 1kg tumor 1~3y 5~20y Molecular expression abnormalities normal Gene mutation proliferation precancerous lesion cancer Onset of symptoms death metastasis difficult to detect the tumor early Gene technology Early gene mutation ？ Gene mutation Metabolic and organical abnormality time Tumor size Omics Genomics Proteinomics Metabolomics Transcriptomics Lipidomics Immunomics Glycomics Rnomicsc Radiomics * * ?systemic research for different sets of research subjects solid cancer are heterogeneous in space and time Radiomics Lambin the high-throughput extraction of large amounts of image features from radiographic images Kumar extraction and analysis of large amounts of advanced quantitative imaging features with high throughput from medical images obtained with CT,PET or MRI Mitra high-throughput automated (or semiautomated) extraction of large amounts of quantifiable information(or image features) from radiographic images for an improved management of the disease * * Lambin,E.…… R.J.Gillies, et al. Radiomics: Extracting More Information from Medical Images Using Advanced Feature Analysis. Eur J Cancer 2012;48:441-6. Kumar,V.…… R.J.Gillies, et al. Radiomics: The Process and the Challenges. Magn Reson Imaging 2012;30:1234-48. Mitra,S. and B.U.Shankar. Integrating Radio Imaging with Gene Expressions toward a Personalized Manageme