干细胞移植治疗糖尿病伤口愈合的进展progressinthe-药学学报.pdfVIP

· · 药学学报 Acta Pharmaceutica Sinica 20 15, 50 ( 1): 1 6 1 ·综述· 细胞移植治疗糖尿病伤口愈合的进展 蔡清鑫, 王 璐, 张 妍, 杨宝峰* (哈尔滨医科大学, 黑龙江 哈尔滨 150081) 摘要: 近年来, 糖尿病的患病率呈逐年升高趋势。其中, 伤口愈合迟缓是常见的糖尿病并发症, 严重影响人 们的正常生活, 因此, 探究及寻找糖尿病患者伤口愈合分子机制及其治疗方法有重要临床意义。干细胞移植促进 糖尿病伤口愈合是近年来的研究热点。本文综述了国内外干细胞移植促进糖尿病伤口愈合的研究进展, 并展望 干细胞治疗糖尿病伤口的临床应用。 关键词: 管新生; 糖尿病伤口; 生长因子; 干细胞 中图分类号: R963 文献标识码: A 文章编号: 0513-4870 (20 15) 0 1-0001-06 Progress in the treatment of diabetic wound healing via stem cells transplant * CAI Qing-xin, WANG Lu, ZHANG Yan, YANG Bao-feng (Harbin Medical University, Harbin 150081, China ) Abstract : The morbidity of diabetes has been increasing rapidly in recent years. Delayed wound healing has become a common complication in diabetes, which seriously affects the orthobiosis of patients. Exploring and finding the molecular mechanisms of diabetic wound healing and the effective therapies to promote wound healing have important clinical significances. Stem cells transplant has become a research hotspot in accelerating diabetic wound healing. This article reviewed the present approaches concerning stem cells transplant in diabetic wound healing both at domestic and abroad, and looked forward the clinical therapy of stem cells on diabetic wound healing. Key words: angiogenesis; diabetic wound healing; growth factor; stem cell 皮肤伤口愈合是一个复杂的生物整