宿主基因单核苷酸多态性与幽门螺杆菌相关胃癌-遗传.pdfVIP

HEREDITAS (Beijing) 2011 2 , 33(2): 109 ―116 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2011.00109 宿主基因单核苷酸多态性与幽门螺杆菌相关胃癌 何彩云, 袁媛 , , 110001 幽门螺杆菌相关胃癌是一种由遗传、环境、生活方式等因素共同作用所致的特殊类型胃癌。它的发病过 程至少包括炎症、萎缩和癌变 3 个主要阶段。宿主基因单核苷酸多态性(SNP)包括炎症反应、胃酸抑制、免疫 识别等相关基因SNP, 可能特异性参与了幽门螺杆菌相关胃癌发生发展过程中的不同阶段。文章综述与幽门螺 杆菌相关胃癌发病3 个主要病理阶段相关的宿主基因SNP 及其与胃癌发病风险关系的研究进展。 幽门螺杆菌相关胃癌; SNP; 宿主; 相关性 Single nucleotide polymorphisms and helicobacter pylori-related gastric cancer HE Cai-Yun, YUAN Yuan Cancer Control Laboratory of Cancer Institute and General Surgery, Key Laboratory of Cancer Control in Liaoning Province, the First Affiliated Hospital of China Medical University , Shenyang 110001, China Abstract: Helicobacter pylori-related gastric cancer is a special-type gastric cancer determined by genetic, environmental, and life style factors. A series of single nucleotide polymorphisms (SNPs) of susceptibility genes, including inflamma- tion-related genes, gastric acid inhibition-related genes, and immune response-related genes, could be specifically involved in the development of Helicobacter pylori-related gastric cancer that consists of three major stages: Helicobacter pylori infection, gastric atrophy development, and carcinogenesis. The aim of the present paper was to review and evaluate the most recently published evidence on the contribution of SNPs to the carcinogenesis of Helicobacter pylori-related gastric cancer in humans. Keywords: helicobacter pylori-related gastric cancer; SNP; host; association , , 3 (Helicobacter pylori, Hp), ; Hp Hp[1] , p