间充质干细胞影响肿瘤细胞增殖及其分子机理.pdfVIP

15 卷 5 期 命科学研究 燥造援员5 晕燥援5 圆园11 年 10 月 蕴蚤枣藻 杂糟蚤藻灶糟藻 砸藻泽藻葬则糟澡 Oct. 圆园11 综 述 间充质干细胞影响肿瘤细胞增殖及其分子机理 * 秦 翔, 宋关斌 , 罗 庆, 石轶松 (重庆大学生物工程学院, 中国重庆400044) 摘 要: 间充质干细胞MSCs(mesenchymal stem cells)与肿瘤细胞间的相互作用是近年来肿瘤领域的研究热点 之一. MSCs 是一种多能干细胞, 具有分化为成骨细胞 软骨细胞 脂肪细胞 纤维母细胞或肌肉细胞等多种间 充质细胞的能力. MSCs 在肿瘤细胞中表现出的归巢和转移能力为其成为潜在的抗肿瘤工具奠定了基础, MSCs 转移到肿瘤细胞后参与重塑肿瘤微环境, 并对其增殖 侵袭和转移等生物学行为 生重要影响. MSCs 重塑肿 瘤微环境后对肿瘤细胞的增殖究竟是促进还是抑制, 相关文献报道有很大的争议. 基于相关研究近况, 主要综 述骨髓间充质干细胞BMSCs (bone marrow derived mesenchymal stem cells)参与重塑肿瘤微环境对肿瘤细胞增 殖的影响, 并就已知的分子机理做一简要介绍. 关键词: 间充质干细胞; 肿瘤; 微环境; 增殖 中图分类号: R730.1 文献标识码: A 文章编号: 1007鄄7847(2011)05鄄0460鄄06 Effects of Mesenchymal Stem Cells on Proliferation of Tumor Cells and its Molecular Mechanism * QIN Xiang, SONG Guan鄄bin , LUO Qing, SHI Yi鄄song (College of Bioengineering, Chongq ing Univers ity, Chongqing 400044, China) Abstract: The interaction of mesenchymal stem cells (MSCs) and tumor cells has become a hot point of can鄄 cer research. MSCs are multipotent stem cells that can differentiate into several mesenchymal cells, such as osteoblast, chondrocyte, adipocyte, fibroblast and muscle cells. The innate tropism of MSCs to tumors makes MSCs uniquely destined as a potential antitumor weapon. The homing mechanism of MSCs was involved in tumor microenvironment remolding and regulating proliferation and migration of tumor cells. However, there were still no consistant results reported. Here, the influence of bone marrow derived mesenchymal stem cells (BMSCs) on tumor proliferation and