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* Overview: Treatment of HCV Infection Jürgen Rockstroh Department of Medicine I, University of Bonn, Germany ICVH Baltimore 2011 4/22/2011 Discovery of Hepatitis C 4/22/2011 ICVH Baltimore 2011 Treatment of HCV Epidemiology Natural history Staging of liver disease and indications for therapy Predictors of treatment success Treatment recommendations Shift in treatment paradigms ICVH Baltimore 2011 4/22/2011 Source: WHO 2002 4/22/2011 ICVH Baltimore 2011 Estimated 180 Million individuals infected with HCV worldwide /immunization/topics/hepatitis_c/en/. Worldwide Distribution of HCV Genotyp