解淀粉芽孢杆菌SSY1株的安全性试验-论文.pdfVIP

2017 44 3 928934 China A nim al H usbandry Vete r inary M e d ic ine doi cnki j SSY 1 SSY CFU mL CFU mL CFU mL d CFU mL CFU mL CFU mL d d P SSY SSY S A Evaluation of Safety of Bacillus amy loliquef aciens SSY1 WANG Yan CHEN Nannan HOU Meiru YIN Jun i LIU Yu y Z HOU Qingmin QIN Pingw ei SHI Tong rui Heilon iang I nstitute o Veterinar Medicine Science Qi ihaer China gj f y q Abstract In order to determine the saf ety of B ac illus amy loliq uef ac iens SSY w e carried out the acute tox icity chronic tox icity bacterial translocation roduct of metabolism and drug sus p ceptibility test Acute toxicity test in high dose groups CF U m L middle do se g roup CF U m L low do se group CFU m L and normal saline control g roup Af ter the acute toxicity test the mice w ere sacrif iced day s af ter the observation Chro nic tox icity test of each group w as administered once a day f or d chronic tox icity test in high dose groups CFU m L middle dose group CFU m L low dose g roup CFU m L and normal