湘雅儿科课件-新生儿缺氧缺血性脑病（可编辑）.docVIP

湘雅儿科课件-新生儿缺氧缺血性脑病 Hypoxic-Ischemic EncephalopathyHIE Department of pediatrics 陈平洋 第七章第六节 中南大学儿科学教研室 PurposeTo be familiar with etiology, Mechanism and preventionTo master clinical manifestation, diagnosis and treatmentTo understand the prognosis SummaryHIE(缺氧缺血性脑病)is caused by perinatal asphyxia(围生期的窒息) HIE is a disease primarily of theterm infant Hypoxia(低氧血症)cerebral metabolism (脑代谢)disorder acidemiaATP Na .Ca pump function ↓ cellular Ca.Na ↑ cerebral edema (脑 水肿) diminished cerebral perfusion (脑灌注) ↓ ischemia ↓ cerebral necrosis (脑梗死) cerebral edema Intracranial pressure(颅内压 ↑bl