Cardioprotective effect of erythropoietin on sepsis―induced myocardial injury in rats.docVIP

Cardioprotective effect of erythropoietin on sepsis―induced myocardial injury in rats 　　BACKGROUND： Sepsis-induced myocardial injury is one of the major predictors of morbidity and mortality of sepsis. The cytoprotective function of erythropoietin （EPO） has been discovered and extensively studied. However， the cardioprotective effects of EPO on sepsis-induced myocardial injury in the rat sepsis model has not been reported. METHODS： The rat models of sepsis were produced by cecal ligation and perforation （CLP） surgery. Rats were randomly （random number） assigned to one of three groups （n=8