基于多胺转运系统的抗肿瘤药物研究进展.PDFVIP

生物技术通报 ·综述与专论· BIOTECHNOLOGY BULLETIN ( ) 2017, 33 5 :34-39 基于多胺转运系统的抗肿瘤药物研究进展 李建明  丁劲松 （中南大学湘雅药学院，长沙 410013） 摘 要 ： 多胺是维持细胞生长分化等生命活动的必需物质。肿瘤的增殖与细胞内多胺水平密切相关，利用肿瘤细胞膜表面 高表达的多胺转运系统介导多胺类似物和缀合物进入细胞，可耗竭细胞内多胺并诱导肿瘤细胞凋亡。也可利用多胺聚阳离子的结 构特点进行基因递送，提高外源基因的转染效率。综述了基于多胺转运系统的多胺类似物，缀合物和基因递送的癌症治疗研究进展， 旨为以多胺结构为基础的抗肿瘤药物研究提供参考。 关键词 ： 多胺转运系统；多胺类似物；多胺缀合物；肿瘤靶向 ；基因递送 DOI ：10.13560/ki.biotech.bull.1985.2017.05.005 Drug Research in Cancer Therapy Based on Polyamine Transport System LI Jian-ming DING Jin-song （Xiangya School of Pharmaceutical Sciences ，Central South University ，Changsha 410013 ） Abstract: Polyamine is an essential substance in cells growth，differentiation and other life activities. The proliferation of tumor is closely related to the level of intracellular polyamine. Delivering polyamine analogs and conjugates into cells，mediated by polyamine transport system overexpressed on tumor cell surface，leads to the exhaustion of intracellular polyamine and then induces tumor cells apoptosis. In addition， using the positive structure characteristics of polyamine to deliver therapeutic genes may increase the transfection efficiency of exogenous genes. In order to provide reference for the research of anticancer agents based on polyamine in the future，the research progress on polyamine analogues and conjugates for treating cancer and using polyamine as a gene deliver vector are summarized here. Key words: polyamine transport system ；polyamine analogues ；polyamine conjugates ；tumor targeting ；gene delivery 速酶 ［3］ 多胺是广泛存在