天然植物单体抗结肠癌SW480细胞活性的研究进展-肿瘤药学.PDFVIP

肿瘤药学 2015 年 4 月第 5 卷第 2 期　Anti-tumor Pharmacy, April 2015, Vol. 5, No. 2 - 97 - ●综　　述● 天然植物单体抗结肠癌 SW480 细胞活性 的研究进展★ 肖忠华，李　 晶，黄海兵 ，苗加伟 ，李毓强 （重庆三峡 医药高等专科 学校 ，重庆，404 120 ） 摘要：结肠癌是临床上常见的恶性肿瘤，当前的化学药物治疗仍具有严重的毒、副作用，开发毒性低、副作 用小的抗结肠癌药物的任务十分迫切。中草药的有效活性成分是筛选抗癌药物的重要来源，从天然植物中提 取的多酚类、苷类、有机硫化物及异戊二烯类等物质可通过直接杀伤肿瘤细胞、阻滞细胞周期、影响基因表达、 作用于凋亡信号传导途径和诱导细胞分化等机制在体外表现出显著的抑制人结肠癌 SW480 细胞生长的活性。 本文综述了近年来发现的具有体外抗 SW480 细胞活性的天然植物单体。 关键词：结肠癌；SW480 细胞；体外抗肿瘤活性；多酚类化合物；苷类化合物 中图分类号：R735.35 文献标识码 ：A 文章编号：2095-1264（2015）02-0097-04 doi：10.3969/j.issn.2095-1264.2015.019 Research Progress of the Antitumor Activity of Monomer from Natural Plant for Human SW480 Colon Cancer Cells in Vitro ★ XIA O Zhonghua, LI Jing, H UANG Haibing, MIA O Jiawei, LI Yuqiang (Chongqing Three Gorges Medical College, Chongqing, 404120, China) Abstract: Human colon cancer is one of the most common malignant tumors. The current treatment of chemical drugs still has serious side effects and toxicity, therefore, it is very urgent to develop drugs with low side effects and toxicity for colon cancer patients. Enriched with active ingredients, Chinese herbal medicine becomes an important resource to screen anti-cancer drugs. Compounds of polyphenols, glycoside, organic sulfide and isoprenoids from natural plants are mark- edly characterized by their antitumor activities in vitro for human SW480 colon cancer cells, by killing tumor cells directly, blocking the cell cycle, affecting the gene expression and apoptosis signal pathways and induction of cell differentiation. This article makes a brief summ