治疗性终止妊娠对妊娠相关乳腺癌患者5年生存率影响的meta分析.docVIP

治疗性终止妊娠对妊娠相关乳腺癌患者5年生存率影响的Meta分析 王虹 刘骙骙 王辉 滨州医学院护理学院成人护理学教研室 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 评价治疗性终止妊娠对妊娠相关乳腺癌患者5年生存率的影响, 以期为临床实践提供循证依据。方法 通过计算机和手工检索全面收集国内外有关妊娠相关乳腺癌两种不同妊娠处理方法 (终止妊娠和继续妊娠) 的队列研究, 使用RevMan5.3软件对两种处理方法患者的5年生存率进行Meta分析。结果 共纳入6篇文献。分析结果显示:两种处理方法对妊娠相关乳腺癌患者5年生存率影响无统计学意义[RR=1.00, 95%CI (0.691.45) , P=0.990.05]。根据乳腺癌TNM分期进行的亚组分析结果亦显示两种处理方法对患者5年生存率影响无统计学差异, 其中Ⅰ期RR=0.99, 95%CI:0.551.76, P=0.83;Ⅱ期RR=0.95, 95%CI:0.461.95, P=0.62;Ⅲ期RR=0.88, 95%CI:0.253.10, P=0.67。结论尚不能认为治疗性终止妊娠对妊娠相关乳腺癌患者的预后有改善作用。不过, 仍需更多大样本的队列研究加以证明。 关键词： 终止妊娠; 乳腺癌; 5年生存率; Meta分析; 作者简介：王虹, E-mail:yiwanghong@163.com 收稿日期：2016-11-30 The 5-Year survival rate of patients with pregnancy-associated breast cancer after therapeutic termination of pregnancy:a Meta-analysis WANG Hong LIU Kuikui WANG Hui Teaching and Research Section of Adult Nursing, School of Nursing, Binzhou Medical University; Abstract： Objective To evaluate the 5-year survival rate of patients with pregnancy-associated breast cancer after therapeutic termination of pregnancy compared with those who continued the gestation, so as to provide an evidence for clinical practice.Methods This project utilized meta-analysis.Computer and manual retrieval was conducted to search literatures on cohort studies comparing the two methods of treatment.RevMan 5.3 software was used for statistical analyses.Results 5 cohort studies were retrieved out.Meta-analyses showed that there was no significant difference between the two methods[RR=1.00, 95% CI (0.691.45) , P=0.990.05〗.Subgroup analysis by TNM staging showed no significant difference, either.In StageⅠ, RR was 0.99, with 95% CI (0.551.76) , and P was 0.83.In StageⅡand Ⅲ, [RR0.95, 95% CI (0.461.95) , P=0.62]and[RR0.88, 95% CI (0.253.10) , P=0.67], respectively.Conclusion Termination of pregnancy demonstrated no significant improvement for the prognosis of the patients with pregnancy-associated breast cancer.While, more large-sample cohort