直肠癌多层螺旋ct灌注参数与临床病理特征的相关性研究.docVIP

直肠癌多层螺旋CT灌注参数与临床病理特征的相关性研究 周志鹏 汤日杰 李建生 陈国硕 陈思远 凌国辉 卢斌贵 广州医科大学附属肿瘤医院放射科 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 探讨直肠癌CT灌注成像参数特点及其与病理分化程度、临床分期的关系。方法 选取24例直肠癌患者治疗前行CT灌注成像扫描, 绘制靶血管、病灶及其邻近正常直肠组织感兴趣区 (region of interest, ROI) 的时间-密度曲线 (time density curve, TDC) , 记录病灶、正常直肠组织的血流量 (blood flow, BF) 、血容量 (blood volume, BV) 、平均通过时间 (mean transit time, MTT) 、血管表面通透性 (vascular Permeability surfaceareaproduct, PS) 和峰值CT值, 并于术后对不同TNM分期及病理分化程度的各灌注参数值进行比较。结果 直肠癌的BF、BV、PS值、峰值CT值明显高于正常组织, MTT值明显低于正常组织, 差异有统计学意义 (t值分别为-3.36、3.18、3.20、4.88、-2.21, 均P0.05) 。不同临床分期组间的各灌注参数值差异均无统计学意义 (t值分别为-0.73、-0.86、-0.28、-1.28, 均P0.05) 。高中分化组直肠癌的BF值明显高于低分化组, 差异有统计学意义 (t=-3.35, P0.05) 。结论 多层螺旋CT灌注成像能一定程度上反映肿瘤内部的血流灌注情况, CT灌注参数对直肠癌与正常组织鉴别、直肠癌分化程度的鉴别均有一定参考意义。 关键词： 直肠癌; 体层摄影术; 螺旋计算机; 灌注成像; 收稿日期：2017-09-23 The Correlation between Multi-slice Spiral CT Perfusion Parameters and Clinical and Pathological Characteristics in Rectal Cancer ZHOU Zhi-peng TANG Ri-jie LI Jian-sheng Department of Radiology, Cancer Center of Guangzhou Medical University; Abstract： Objective To evaluate the relationship between the characteristics of CT perfusion parameters and the degree of pathologic differentiation as well as TNM staging in rectal cancer. Methods 24 patents with histological verified rectal cancer underwent multi-slice spiral CT perfusion scanning before beginning therapy. Time density curves (TDC) were created from the region of interest (ROI) in the target vessels, lesions and normal rectal tissue adjacent to the lesion. The parameters of ROI were measured, such as blood flow (BF) , blood volume (BV) , mean transit time (MTT) , vascular permeability surface area product (PS) and CT enhanced peak, then determined TNM stages and the degree of tumor differentiation after surgery. The correlation between the parameters and the clinical and pathological factors above was studied. Results The rectal cancer tissue showed significantly higher BF, BV, PS and CT enhanced pe