蛋白质表面氨基酸特性进展.pdfVIP

1991 现代生物医学进展 Progress in Modern Biomedicine Vol.11 NO.10 MAY.2011 · · 蛋白质表面氨基酸特性研究进展* 荆 艳 宋晓峰△ (南京航空航天大学生物医学工程系 江苏南京 210016) - 摘要：分布在蛋白质分子表面的暴露于溶剂的氨基酸所具有的一些特性对蛋白质的折叠和聚合过程、蛋白质 蛋白质相互作用以 及蛋白质的功能具有重要影响。本文分析了蛋白质表面氨基酸在疏水性、保守性、静电势及结构方面的一些特性，阐述了近年来 - 国际上利用这些特性对蛋白质 蛋白质相互作用界面进行预测的方法，最后介绍了几款预测蛋白质表面氨基酸的软件。 关键词：蛋白质表面特性；蛋白质相互作用界面；预测方法 Q71 Q517 A 1673-6273 2011 10-1991-04 中图分类号： 文献标识码： 文章编号： （ ） Progress in Properties of Amino Acids on Surface of Protein Molecules* JING Yan, SONG Xiao-feng△ (Dep artment of Biomedical Engineering, Nanj ing University of Aeronautics and Astronautics, Nanj ing, 2 100 16, China) ABSTRACT: The properties of the surface amino acids that exposed to the solvent can influence the fold and polymerization processes, protein-protein interaction and the function of proteins. This paper analyzes the properties of surface amino acids such as hydrophobicity, conservation, electrostatic potential and structural properties. Also, the methods using these properties to predict the interfaces between two interacting proteins in the international filed were reviewed. Finally we introduced several softwares of predicting surface amino acids. Key words: The properties of protein surface; Protein-protein interface; Prediction methods Chinese Library Classification(CLC): Q71 Q517 Document code: A Article ID:1673-6273 2011 10-1991-04 （ ） 1