Fundamentals of Biostatistics：生物统计学基础.pptVIP

Basic Statistical Concepts Fundamentals of Biostatistics Lecture 2 Clinical Trials Validity/Reliability Assessing Evidence Randomized Clinical Trials (RCT) Randomization first used by RA Fisher in agriculture expts in 1920s First clinical trial using randomization in 1931 by Anderson on use of sanocrysin on TB patients. Also, first trial using blinding. Placebo first used in RCT in 1938 in cold vaccine trial. Randomized Clinical Trials (RCT) Fundamental Point: A properly planned clinical trial is a powerful expt’l technique for assessing effectiveness of a drug or intervention. Defn: A