Modern organic synthesis《近代有机合成》精美.pptVIP

It is believed that the more reactive carbonyl group is protected as the hydrate, which is stabilized by complexation with the cerium ion, and is regenerated during the isolation of the product. ? Selective reduction of aldehydes in the presence of ketones can be effected with nBu4NB(OAc)3H and LiAlH[OC(C2H5)3]3. ? ? ? Reduction of ketones with an asymmetric center next to the carbonyl group ?? Cram’s rule (the conformation of the carbonyl compound in the transition state is determined by steric factors) ?? Cram’s rule may not be followed in case where there is a polar group on the ca