3种治疗早期帕金森病用药方案的成本效果分析.docVIP

精品论文 参考文献 3种治疗早期帕金森病用药方案的成本效果分析 （浙江省常山县人民医院 浙江 衢州 324200） 【摘 要】目的：比较3种用药方案治疗早期帕金森病( PD)的治疗效果。方法：80例早期PD患者随机分成3组，分别给予盐酸苯海索片( A组) 、多巴丝肼片( B组) 、多巴丝肼片加用普拉克索片( C组) 治疗，疗程均为12周。采用对照研究方法，比较三组的治疗效果及治疗成本。结果：B组、C组虽然在药物和治疗费用方面较A组明显增加(Plt;0.01)，但其帕金森病综合量表评分显著下降(Plt;0.01)。结论：多巴丝肼治疗早期帕金森病具有明显的经济学优势，是值得推荐的治疗早期帕金森病的一线用药；普拉克索虽然价格昂贵，但能明显改善PD症状，尤其适合应用于PD合并抑郁的患者，应根据患者具体病情、意愿个体化选用最适宜药物治疗。 【关键词】帕金森病；苯海索；多巴丝肼；普拉克索； 【中图分类号】R956 【文献标识码】A 【文章编号】1004-6194（2015）02-0117-01 【Abstract】Objective：To assess the cost-effectiveness of 3 therapeutic schemes in the treatment of early Parkinsons disease( PD) . Methods：A total of 80 PD cases were randomly assigned into 3 groups: group A ( Benzhexol hydrochloride group) ，group B ( Levodopa and Benserazide group) and group C (Pramipexole combined with Levodopa and Benserazide group) .After treatment for 12 weeks，by the control methods, therapeutic effect and treatment cost were compared between the three groups. The curative effects were evaluated by unified Parkinsons disease rating scale（UPDRS）．Results：There were 26 patients in group A，30 patients in group B，and 24 patients in group C．Although B group and C group in drug and treatment costs were increased more significantly than A group（P lt;0.01），but declined markedly UPDRS after treatment than A group（P lt;0.01）. Conclusion：Levodopa and Benserazide Hydrochloride treatment of early Parkinsons disease has obvious advantages in economics, is the first-line drugs for the treatment of early Parkinsons disease recommended；Pramipexole, although expensive, but can obviously improve the symptoms of PD, especially suitable for use in patients with PD complicated with depression, should choose the most appropriate drug therapy according to the specific condition of patients, willingness of individual. 【Key words】Parkinsonrsquo;s disease；Benzhexol；Levodopa and Benserazide；Pramipexole； 帕金森病( PD) 是一种常见的中老年人神经系统变性疾病，以黑质多巴胺能神经元变性缺失和路易小体形成为病理特征。临床表现以静止性震颤、运动迟缓、肌强直和姿势步态障碍为主要特征。如何选择药物早期治