近视动物模型及发病机制的研究进展-中国科技论文在线.pdfVIP

中国科技论文在线 k 近视动物模型及发病机制的研究进展 郭芳，魏瑞华，吴绵绵，孙笑笑，张琰** （天津医科大学眼科医院，天津医科大学眼科研究所，天津医科大学眼视光学院，天津， 5 300384 ） 摘要： 近视已成为一种常见病，影响公众生活质量，危害公众健康。探索其发病机制有助 于疾病的预防和治疗。自20 世纪70 年代发展至今，近视动物模型的相关研究已有进展性的 突破，从分子机制、信号通路、药物干预等方面为近视发病机制的研究提供了证据和思路。 10 然而目前近视发病机制尚不明确。如何合理应用近视动物模型与人类近视相联系，仍然是研 究的重点与难点。现就常见近视动物模型及发病机制的研究进展做一综述。 关键词：近视；动物模型；诱导方法；发病机制 中图分类号：R77 15 Research progress on myopia animal models and the pathogenesis GUOFang, WEI Ruihua, WU Mianmian, SUN Xiaoxiao, ZHANG Yan (Tianjin Medical University Hospital,Tianjin Medical University Eye Institute,College of Optometry and Ophthalmology,Tianjin Medical University, Tianjin 300384, China) 20 Abstract: Myopia has become a common disease all over the world, affecting public quality of life and endangering public health. Exploring the pathogenesis is helpful for the prevention and treatment for myopia. From the 1970s, the research on myopia animal models has made a breakthrough. It has provided valuable evidence and hint for mechanism research from the perspective of molecular mechanism, signal pathway, Drug intervention, etc. However, the mechanism is still not clear. There 25 exists a research hotspot that how to apply reasonably myopia animal models for matching human model . In this paper, the research progess on common myopia animal models and the pathogenesis will be r