G6PD活性与地中海贫血的相关性研究.docVIP

精品论文 参考文献 G6PD活性与地中海贫血的相关性研究 黄佐荣1 苏国生2(通讯作者) 　　（1 广西钦州市钦北区妇幼保健院 广西钦州 535000;2 广西南宁市第四人民医院 广西南宁 530023） 　　【摘要】目的 探讨G6PD活性与地中海贫血的相关性。方法 采用全自动生化仪对患者进行G6PD活性定量分析，用全自动血红蛋白分析系统进行地中海贫血筛查，并对异常结果患者标本进行基因分型确诊。结果 在3626例研究对象中，有652例G6PD活性升高，而G6PD活性升高的患者血红蛋白电泳检测结果异常的几率明显提高，经基因分型确证，轻度alpha;地中海贫血阳性检出率为25.92%，轻型beta;地中海贫血阳性检出率为34.97%，重型beta;地中海贫血阳性检出率为1.53%，地中海贫血总阳性检出率为62.42%，与G6PD活性正常组地中海贫血总阳性检出率比较，chi;2=817.42，P=0.0008，差异具有统计学意义。结论 G6PD活性越高，患地中海贫血的几率越大，认为对患者进行G6PD活性筛查，可有助于地中海贫血的临床诊断。 　　【关键词】G6PD活性 地中海贫血 血红蛋白电泳 基因分型 　　【中图分类号】R556 【文献标识码】A 【文章编号】2095-1752（2014）12-0082-02 　　Correlation of G6PD activity and thalassemia 　　Huang Zuo Rong 1, Su Guosheng 2 　　Guangxi QinZhouShi qin north district maternity and child care (guangxi qinzhou 535000) 　　Fourth Peoples Hospital of Guangxi Nanning (Guangxi Nanning 530023) 　　Corresponding author: Su Guosheng, E-mail: suguoshengv@ 　　【Abstract】Objective To investigate the G6PD activity correlated with thalassemia. Methods automatic biochemical analyzer patients with G6PD activity on quantitative analysis, thalassemia screening using automated hemoglobin electrophoresis analysis system, and abnormal results of patient samples for genotyping confirmed.Results 3626 cases studied, there are 652 cases of G6PD activity increased, and G6PD activity in patients with elevated hemoglobin electrophoresis test results significantly improve the chances of abnormalities, confirmed by genotyping, mild positive rate of alpha;-thalassemia to 25.92%, light beta; thalassemia positive rate was 34.97%, heavy beta; thalassemia positive rate was 1.53%, thalassemia positive rate was 62.42% of the total, with normal G6PD activity thalassemia total positive rate comparison, chi;2= 817.42, P=0.0008, a statistically significant difference. Conclusion G6PD activity is higher, the greater the risk the chance of thalassemia, G6PD activity in patients considered for screening, clinical diagnosis can help thal