乙肝免疫球蛋白阻断乙肝病毒母婴传播效果研究.docVIP

精品论文 参考文献 乙肝免疫球蛋白阻断乙肝病毒母婴传播效果研究 姚　雯　（湖北省仙桃市第一人民医院妇产科　湖北仙桃　433000） 　　[ 摘　要]　目的：分析乙肝免疫球蛋白对于阻断乙肝病毒母婴传播的效果。方法：病例选自我科室门诊2013 年1月～ 2015 年 3 月接受孕期检查的HBV携带的132 例孕妇，大三阳和小三阳的孕妇于孕24 周开始接受HBIG 注射治疗，携带者孕妇于孕28 周开 始接受HBIG 注射。结果：孕24 周与分娩前的乙肝标志物与HBV-DNA检查结果无显著差异（Pgt;0.05）。HBIG阻断HBV母婴传播 疗效，总有效率为75.71%。而HBIG 阻断HBV疗效大三阳孕妇较携带者和小三阳孕妇疗效不佳，存在明显差异。新生儿接受疫苗 接种和HBIG 注射后12 个月，HBsAb（+）率为86.43%，与新生儿出生时HBsAb（+）率75.71% 相比，有较大改善。结论：对HBV 感染的孕妇在孕24 周后注射HBIG，阻断乙肝病毒母婴传播效果明显，新生儿出生后采用HBIG 和HBV疫苗联合阻断HBV母婴传 播临床效果显著。 　　[ 关键词]　乙肝免疫球蛋白；乙肝病毒；母婴传播 　　Abstract: Objective: To analyze the effects of hepatitis b immunoglobulin for blocking the hepatitis b virus mother-to-child transmission. Methods: A total of 132 cases pregnant women that confirmed as HBV carrier that visited our hospital during January 2010 and March 2011 were enrolled in this study， those shown HBsAg, HBeAg and Anti-HBc positive or HBsAg, Anti-HBe and Anti-HBc positive started to get HBIG injection from the 24th week of pregnancy， while HBV carriers started on the 28th week of preganancy. Results: Efficiency of HBIG blocking HBV mother-to-child transmission was 75.71%. But the efficiency of HBIG for blocking HBsAg， HBeAg and Anti-HBc positive or HBsAg, Anti-HBe and Anti-HBc positive pregnant women was different. For new born infants， after injection of HBIG， 86.43% were shown as HBsAb(+), which is improved comparing with the 75.71% before injection. Conclusion: After injection of HBIG on the 24th week of pregnancy， effects of blocking the hepatitis b virus mother-to-child transmission in pregnant women with HBV infection is obvious， for new born infants, HBIG combing with HBV is effective on blocking HBV mother-to-child transmission. Key Words: Hepatitis b immunoglobulin; Second liver virus; Mother-to-child transmission 　　[ 中图??类号]　R6 [ 文献标识码]　B [文章编号]　1004-1620（2015）10-019-02 　　我国是乙型肝炎病毒（hepatitis Bvirus，HBV）高发流行 地区，该病毒是导致慢性肝炎、肝硬化、肝癌的重要原因[1，2]。 母婴垂直传播已经成为慢性乙型肝炎的重要传播途径，大约有 30% ～ 50% 的HBV 携带者是由于母婴传播所导致[3-4]。因此， 阻断HBV 母婴传播途径是控制其流行的关键。目前，乙肝免疫 球