云浮市新生儿2010-2011年G6PD缺乏症现状分析.docVIP

精品论文 参考文献 云浮市新生儿2010-2011年G6PD缺乏症现状分析 冯锦文 周丽银（广东省云浮市妇幼保健院 527300） 【中图分类号】R195【文献标识码】A【文章编号】1672-5085（2011）40-0015-03 【摘要】目的 了解云浮市新生儿G6PD缺乏症的发生率。方法 对出生48～72h后的32237名新生儿（男婴17988人，女婴14249人）采集足跟血制作血滤纸干标本，采用荧光斑点定性试验测定G6PD活性。结果 初筛G6PD缺乏阳性2648人，其中男婴2152人，女婴496人，总的G6PD缺陷初筛检出率为8.21%，云浮市发病率与广东其他地区差别有统计学意义（Plt;0.05）。其中男婴为11.9%，女婴为3.48%。经统计分析显示男婴与女婴的发病率差别有统计学意义（Plt;0.05），并且云浮市各地区的发病率差别也存在差异，有统计学意义（Plt;0.05）。结论 云浮市新生儿G6PD缺乏症发生率明显高于广东省其他地区，而且G6PD缺乏者男性明显高于女性，并且云浮市各地区的G6PD缺乏症发病率不一样。因此应在新生儿进行常规筛查，有效预防由于G6PD缺乏而引起的一系列疾病的发生。 【关键词】G6PD缺乏症 发生率 新生儿 【Abstract】 Object: Yunfu neonatal about the incidence of G6PD deficiency.Methods: For 48 ～ 72h after birth of 32 237 newborns (male 17,988 people, 14,249 were girls) making blood spots collected dry heel blood samples, measured by fluorescent spot test qualitative G6PD activity. Results: G6PD deficiency screening positive for 2648, of whom 2152 were boys, 496 girls, with a total of G6PD deficiency screening detection rate of 8.21%, Yunfu City, Guangdong, the incidence of other regions with statistically significant difference (P lt;0.05) . One male was 11.9%, girls 3.48%. The statistical analysis showed that the incidence of baby boy and girl difference was statistically significant (Plt;0.05), and Yunfu City, the region there are also differences in the incidence difference was statistically significant (Plt;0.05). Conclusion: Yunfu Neonatal G6PD deficiency was significantly higher than other parts of Guangdong Province, and G6PD deficiency male than female, and all regions of Yunfu City, the incidence of G6PD deficiency is not the same. Therefore, routine newborn screening should be to prevent the G6PD deficiency brought about a series of diseases. 【Key words】 G6PD deficiency Incidence Newborn 云浮市新生儿筛查中心负担着全市77个医疗保健机构的新生儿疾病的筛查工作，主要包括G6PD、PKU、TSH的筛查。新生儿疾病筛查是指在新生儿期对严重危害新生儿健康的先天性、遗传性疾病施行专项检查，提供早期诊断和治疗的母婴保健技术。新生儿疾病筛查是提高出生人口素质，减少出生缺陷的预防措施之一。 红细胞葡萄糖-6-磷酸脱氢酶(glucose-6-phosphate dehydrogenase G6PD)缺乏症是人类最常见的遗传性酶缺陷病,呈X染色体连