结缔组织生长因子在肾间质纤维化中的表达及其调控-中国病理生理杂志.PDF

Ch nese Journal of Pathophys ology 2004, 20( 9) : 1725- 1728 ! 1725 ! [ ] 1000- 4718( 2004) 09- 1725- 04 * 刘 燕, 樊均明 ( , 610041) Expression and modulation of connective tissue growth factor in renal interstitial fibrosis LIU Yan, FAN Jun- m ng ( Dep artment fo N ep hrop athy , West China H osp ital fo Sichuan Univ ersity , Chengdu 610041, China) A Review CTGF, a member of the CCN fam ly of mmed ate early genes, s a recently d scovered prof brot c growth factor, wh ch s nvolved n many pathophys olog c procedures. CTGF acts as a downstream effector of TGF- act ng on nt erst t al cells to enhance the progress on of f brot c renal d seases. It has been shown that CTGF gene express on can be nduced or blocked by some k nds of cytok ne and drugs. It s an nter est ng cand date target for future ntervent on strateg es of renal nterst t al f bros s. [ ] ; ; [KEY WORDS Connect ve t ssue growth factor; Transform ng growth f actor- ; Renal nterst t al f bros s [ ] R363 [ ] A [ 1] Nov) , CTGF Cyr61( cyste ne - , r ch 61) ( nephroblastoma overexpressed, Nov) , - ( transform ng CCN WISP - 1 growth factor- , TGF - ) (Wnt - nduc ble secreted prote n - 1) WISP - 2 [ 26, 27] , WISP- 3 TGF- TGF- ( connect ve CTGF 349 , t ssue growth factor, CTGF) , CTGF 38 kDCTGF ( human umb l cal ve n endothel al cell, HUVEC- con , CTGF [ 2] d t oned) CTGF , TGF- 6q231, 5 , 4 CTGF , 38 , 4 CTGF 1 CTGF