发作性睡病研究进展.pdfVIP

中国现代神经疾病杂志 年 月第 卷第 期 ·644 · 2017 9 17 9 Chin J Contemp Neurol Neurosurg, September 2017, Vol. 17, No. 9 专题综述 · · 发作性睡病研究进展 肖伏龙 张俊 韩芳 【摘要】 下丘脑 （ ） 能系统的发现及其与发作性睡病之间的关系是睡眠医学 Hypocretin Hcrt /Orexin 领域的重大研究进展之一。Hcrt/Orexin 是睡眠 觉醒周期调节的主要促醒物质。相关研究成果业已转⁃ 化为临床应用，其中脑脊液Hcrt/Orexin 测定已作为发作性睡病的诊断“金标准”和分型依据。发作性睡 病患者下丘脑Hcrt/Orexin 能神经元凋亡的遗传免疫学机制研究也获得突破性进展。针对Hcrt/Orexin 受 体的药物也成为睡眠障碍药物治疗的新靶点。 【关键词】 发作性睡病； 综述 Researchprogressofnarcolepsy 1 2 1 XIAO Fu⁃long , ZHANG Jun , HAN Fang 1Sleep Medicine Center, Department of Respiratory Medicine, 2Department of Neurology, Peking University Peoples Hospital, Beijing 100044, China Corresponding author: HAN Fang (Email: hanfang1@) 【 】 Abstract The discovery of hypothalamus Hypocretin (Hcrt)/Orexin system and its relationship with narcolepsy is one of the major advances in sleep medicine. Hcrt/Orexin is a significant neurotransmitter in the circadian cycle of arousal. Basic research about Hcrt/Orexin system has been applied in clinical practice and the measurement of Hcrt/Orexin in the cerebrospinal fluid (CSF) is the golden criteria and classification basis for diagnosis of narcolepsy. Breakthrough advance has been made in genetic immunology of hypothalamus Hcrt/Orexin neuronal apoptosis of narcolepsy patients. Medications aimed at Hcrt/Orexin receptors are considered to be a novel target in the treatment of sleep disorders. 【 】 Keywords Narcolepsy; Review This study was supported by the National Basic Research Development Program of Ch