麻省理工学院 生物材料课程 lecture 18 Drug Delivery Controlled Release Chemically-controlled Devices.pdf

Lecture 18: Drug Delivery: Controlled Release Chemically-controlled Devices 3.051J/20.340J Materials for Biomedical Applications, Spring 2006 1 Drug Delivery System (DDS) Controlling delivery rate and Site-specific delivery of drugs Current drug administration Toxic level Drug conc. Controlled (or Sustained) Release Minimum effective level Time 2 Even though controlled release can be achieved… Spread over body Site-specific delivery Active or passive targeting might cause side effect. 3 Table Controlled Release DDS Diffusion-controlled DDS Reservoir and monolithic systems Water penetration-controlled DDS Osmotic and swelling-controlled systems Chemically-controlled DDS Biodegradable reservoir and monolithic systems Biodegradable polymer backbones with pendant drugs Responsive DDS Physically- and chemically-responsive systems Mechanical, magnetic- or ultrasound-responsive systems Biochemically-responsive; self-regulated systems Particulate DDS Microparticulates Polymer-drug conjugates Polymeric micelle systems Ratner, et al. Biomaterials Science Liposome systems 4 Chemically-controlled DDS