麻省理工学院 生物材料课程 Lecture 9 Surface Modification of Biomaterials Supporting notes.pdf

Lecture 9: Surface Modification of Biomaterials Supporting notes 3.051J/20.340J Materials for Biomedical Applications, Spring 2006 1 Purpose: Alter surface properties to enhance performance in biological environment while retaining bulk properties of device The modified zone at the surface of the device should be as thin as possible. Ideally 1 nm 2 Specific objectives: 1. Clean a surface 2. Reduce/eliminate protein adsorption 3. Reduce/eliminate cell adhesion 4. Reduce bacterial adhesion 5. Reduce thrombogenicity 6. Promote cell attachment/adhesion 7. Alter transport properties 8. Increase lubricity 9. Increase hardness 10.Enhance corrosion/degradation resistance 3 Preparation of non-fouling surfaces to prevent non-specific protein/cell or bacterial adhesion to reduce thrombogenicity Figure by MIT OCW. Surfaces should be hydrophilic or very hydrophobic. 4 Example of “gold standard” Surface modification with PEO derivative. PEO-PPO-PEO, Pluronic Physical adsorption Chemical immobilization Short-time use Long-time use Ex. Drug delivery 5 Other strategies for hydrophilic surfaces 1 Albumin coating surface Phospholipid-mimicking surface N+ N+ N+ N+