人工合成麝香的环境污染、生态行为与毒理效应研究进展.doc

人工合成麝香的环境污染、生态行为与毒理效应研究进展 周启星1, 3, *，范 飞1, 2，王美娥1，祝凌燕3 1．中国科学院沈阳应用生态研究所，中国科学院陆地生态过程重点实验室，沈阳110016 2．中国科学院研究生院，北京100039 3．南开大学环境科学与工程学院，天津300071 2010-02-05 录用日期： 摘要：人工合成麝香作为一种替代型香料被广泛应用于日用化工行业，由于其持续不断地输入环境，其中的一些典型化合物如加乐麝香吐纳麝香等在水、土壤和大气环境中的浓度日益，并且在动物体和人体组织中产生了蓄积作用，其效应相当于持久性有机污染物。因此工合成麝香作为一种新型污染物，已成为药和个人护理品（PPCPs）的重要组成部分。对人工合成麝香的种类与应用情况、环境来源和污染水平介绍。在此基础上，从人工合成麝香的生物蓄积行为、环境降解行为和生物转化行为等3个方面，对人工合成麝香所具有的持久性有机污染物的行为特征进行了分析；概述了人工合成麝香环境激素毒性、遗传毒性效应、生理毒性、对酶活性的影响以及对微生物毒性效应的研究进展，展示了人工合成麝香所可能产生的不良生态效应。最后，根据目前对人工合成麝香的研究进展，提出了今后有关重点研究内容的建议，为合理评价和降低人工合成麝香的生态风险提供理论基础。 Researching progresses in environmental pollution, ecological behaviors and toxicological effects of synthetic musks ZHOU Qixing1, 3, *，Fei1, 2，W Meie1，Key Laboratory of Terrestrial Ecological Process, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016 2. Graduate School and the Chinese Academy of Sciences, Beijing 100039 3. College of Environmental Science and Engineering, Nankai University, Tianjin 300071 Received 5 February 2007; accepted Abstract: As the substituted fragrances, synthetic musks are widely used in the personal care products industry. Due to the continuous input to environment, some typical synthetic musks such as Galaxolide and Tonalide are being increased in water, soil and air, and have been accumulated in tissues of animals and human beings. As a result, the presence of synthetic musks in environment was just like persistent organic pollutants (POPs). Therefore, synthetic musks have been considered as emerging organic pollutants in the pharmaceutical and personal care products (PPCPs) pollution. In this paper, the types and application situation of synthetic musks and their environmental sources and pollution levels were briefly introduced. Then, the behavior properties of synthetic musks as POPs were analyzed on the basis of their biological accumulation, environmental degradation and biological transformation. Some visible adverse ecological effects including environm