SEOM guidelines 西班牙肿瘤内科医学会非小细胞肺癌治疗指南.pdf

Clin Transl Oncol (2009) 11:284-289 DOI 10.1007/s12094-009-0356-4 E D U C AT I O N A L   S E R I E S   Y e l l o w   S e r i e s * AdvAnces in clinicAl mAnAgement And therApy of cAncer SEOM guidelines for the management of non-small-cell lung cancer (NSCLC) Enriqueta Felip · Pilar Garrido · José Manuel Trigo · Marta López-Brea · Luis Paz-Ares · Mariano Provencio · Dolores Isla Received: 6 February 2009 / Accepted: 2 March 2009 Introduction 90% of lung cancer mortality among men (and 80% among women) is attributable to smoking. Lung cancer is currently the most common malignancy and also the leading cause of mortality related to cancer in the world [1]. The crude incidence of lung cancer in the EU is 52.5/100,000/year, while the mortality 48.7/100,000/year. Diagnosis and staging Among men the rates are 82.5 and 77.0/100,000/year, and among women 23.9 and 22.3/100,000/year, respectively. Diagnosis Non-small-cell lung cancer (NSCLC) accounts for 80% of all cases. In Spain, there were 16,879 deaths in men, Pathologic lung cancer diagnosis should be made according with a mean age of 68 years, and 2634 deaths in women, to the WHO classification. Histologic or cytologic speci- with a mean age of 66 years. The incidence of lung cancer mens can be obtained from the primary tumour, lymph in Spain was 68.3/100,000 among men and 13.8/100,000 nodes or metastatic sites. among women, according to the latest data published in the After the initial diagnosis, accurate staging is crucial year 2006 by the Instituto Nacional de Estadística. About for determining the appropriate approach and for tailoring