钙化性主动脉瓣疾病患者血清免疫球蛋白e水平的-国家心血管病中心.pdfVIP

中国循环杂志 2016 年 3 月 第 31 卷 第 3 期（总第 213 期）Chinese Circulation Journal，March，2016，Vol. 31 No.3（Serial No.213） 263 临床研究 钙化性主动脉瓣疾病患者血清免疫球蛋白 E 水平的变化 * 郑韵仪，曾庆春 ，詹琼，朱丁季，华经海，周浩斌，安冬琪，刘祖恒，赖文岩，许顶立 摘要 目的：探讨血清免疫球蛋白 E（IgE）水平与钙化性主动脉瓣疾病（CAVD）的关系。 方法：符合入选标准的 394 例患者根据超声心动图结果分为 CAVD 组（n =169）和非 CAVD 组（non-CAVD 组， n =225）。采用化学发光法测定血清 IgE 水平，分析两组患者间血清 IgE 水平的差异以及血清 IgE 水平与 CAVD 之间的 关系。 结果：CAVD 组患者血清 IgE 水平显著高于 non-CAVD 组（113.30 IU/ml vs 63.76 IU/ml, P 0.05），多因素 Logistic 回归分析也提示两组间血清 IgE 水平的差异有统计学意义（ P 0.05），且血清 IgE 水平与 CAVD 显著相关。 结论：CAVD 组患者血清 IgE 水平显著增高；血清 IgE 水平是提示 CAVD 的独立生化指标，IgE 可能在 CAVD 的 发病过程中起重要作用。 关键词 心脏瓣膜疾病；动脉粥样硬化；免疫球蛋白 E；肥大细胞；炎症 Alterated Serum Levels of Immunoglobulin E in Patients With Calcific Aortic Valve Disease ZHENG Yun-yi, ZENG Qing-chun, ZHAN Qiong, ZHU Ding-ji, HUA Jing-hai, ZHOU Hao-bin, AN Dong-qi, LIU Zu-heng, LAI Wen-yan, XU Ding-li. Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou (510515), Guangdong, China Corresponding Author: XU Ding-li, Email: dinglixu@ Abstract Objective: To explore the relationship between serum levels of immunoglobulin E (IgE) and calcific aortic valve disease (CAVD) in relevant patients. Methods: A total of 394 patients were enrolled in our study. Based on echocardiography presentation, the patients were divided into 2 groups: CAVD group, n =169 and Non-CAVD group, n =225. Serum levels of IgE were examined by chemiluminescence method. The IgE levels were compared between 2 groups and the relationship between serum IgE level and CAVD was analyzed. Results: Serum levels of IgE in CAVD group was significantly higher than Non-CAVD group 113.30 IU/ml vs 63.76 IU/ml (P0.05); multivariate logisti