化痰散瘀法对中晚期食管癌放疗增效的研究-中医临床研究.PDFVIP

- 4 - CIAC 2013 首届国际中医肿瘤暨疑难杂症高峰论坛 化痰散瘀法对中晚期食管癌放疗增效的研究 Clinical Research on resolving phlegm and dissipating blood stasis therapy in improving the effect of radiotherapy for advanced Esophageal Cancer 马纯政 1 王 蓉 1 王怀璋 2 黄 莉 1 刘培民 1 （1.河南省中医院肿瘤科，河南 郑州， 450002； 2.河南省肿瘤医院，河南 郑州，450003） 中图分类号：735.2 文献标识码：B 文章编号：CCAC(2013)-08-0004-04 【摘 要】目的：探讨化痰散瘀法提高中晚期食管癌放疗效果的机理。方法：采用多中心对照研究，将 60 例食管癌患者随机分为治疗组和对照组，各 30 例；治疗组采用放疗加中药治疗，对照组单纯放疗，放疗结束 后评价疗效。结果：治疗组在降低症状积分、改善患者生活质量、提高瘤体稳定率、保护骨髓等方面都优于对 照组。结论：化痰散瘀法能提高接受放疗的中晚期食管癌患者临床缓解率及肿瘤稳定率，改善临床症状和患者 生存质量，减轻放疗对骨髓的毒性，可以达到对放疗的增效减毒作用。 【关键词】食管癌；化痰散瘀法；放疗；增效减毒 【Abstract 】 Objective: To investigate the mechanism of resolving phlegm and dissipating blood stasis therapy in improving the effect of radiotherapy for advanced esophageal cancer. Methods: A multicenter and randomized study was performed. The 60 cases of esophageal cancer patients were randomly divided into two groups and administrated with radiotherapy or radiotherapy combined with resolving phlegm and dissipating blood stasis therapy. We evaluated the curative effect after radiotherapy. Results: The treatment of resolving phlegm and dissipating blood stasis therapy combined with radiotherapy could reduce the symptom score, improve the quality of life, elevate the tumor stable rate, and relieve bone marrow suppression controlled with single radiotherapy. Conclusions: The treatment of resolving phlegm and dissipating blood stasis therapy could improve the clinical curative effects and reduce toxicity of radiotherapy, which included elevating the response rate and tumor stable rate, improving the clinical symptoms and quality of life, and reducing the toxicity on bone marrow of radiotherapy in patients with advanced esophageal cancer. 【Key words 】Esopha