己烯雌酚治疗鼻中隔穿孔的疗效观察.docVIP

己烯雌酚治疗鼻中隔穿孔的疗效观察 赵勇 文庆波 　　（河南焦作煤业集团中央医院耳鼻咽喉科 454000） 　　【摘要】目的 了解已烯雌酚在鼻中隔穿孔上皮修复中的疗效。方法 选择穿孔直径lt;1.0cm的鼻中隔穿孔患者30例随机分为2组，治疗组穿孔双侧缘周作1-2mm创口,用浸润已烯雌酚注射液的棉片贴敷,隔日1次，连续7～14d，观察局部黏膜修复情况；对照组采用0.9%氯化钠注射液棉片贴敷，方法同治疗组。结果 治疗组15例患者全部愈合,穿孔症状随创面渐渐愈合而消失，2例鼻干燥主诉存在。随访6个月，未发现再穿孔者，无局部和全身不良反应；对照组15例患者有3例穿孔愈合，治愈率与治疗组比较差异有统计学意义plt;0.01。结论 已烯雌酚注射液在治疗穿孔lt;1.0cm的鼻中隔穿孔中，疗效确切，无明显手术创伤，操作及观察容易，价格低廉，无不良反应，作为一种非手术治疗鼻中隔穿孔的方法值得临床推广。 　　【关键词】 已烯雌酚 鼻中隔穿孔 　　【中图分类号】R969 【文献标识码】A 【文章编号】2095-1752（2014）09-0112-02 　　 　　The curative effect of Diethylstilbestrol injection in treatment of nasal septum perforation 　　ZHAO Yong WEN Qingbo 　　（Jiaozuo Coal Industry Group Central Hospital, Henan 454000) China 　　【Abstract】 Objective: To evaluate the repairing effect of diethylstilbestrol injection in mucosa injury of nasal septum. Method Selected nasal septum perforation 30 cases were randomly divided into 2 groups, whose perforation diameter lt;1.0cm. In the treatment group, 15 cases with perforation of nasal septum were made about 1-2mm new wound surface around perforation, the cotton piece infiltrated by diethylstilbestrol injection was sticked directly to the surface of perforation, once every other day, for 7-14 days, to observe the repair of local mucosal. In the control group, sticking the surface of perforation with the cotton piece infiltrated by 0.9% sodium chloride injection, the method was same as the treatment group. Results In the treatment groups, 15 cases of perforation were cured, the symptoms disappear gradually, 2 cases of nasal dryness complained of existence. There is no reperforation during follow-up six months, and without local and systemic adverse reactions; In the control group of 15 patients, there were 3 cases of perforation were healing, The cure rate of treatment group and control group had significant difference plt;0.01.Conclusion The curative effect of diethylstilbestrol injection in the treatment of perforation of the nasal sep