2011-2014年耐药菌株的临床分布及耐药性探讨.docVIP

精品论文 参考文献 2011-2014年耐药菌株的临床分布及耐药性探讨 新疆昌吉州人民医院检验科 新疆昌吉 831100 【摘 要】目的 了解本院2011年1月-2014年12月临床分离的排列在前3位的革兰氏阴性杆菌的临床分布及对抗菌药物耐药性的变化趋势。方法 对临床分离的病原菌采用回顾性分析的方法，用VITEK2compact全自动细菌分析仪鉴定菌株及药敏试验。结果 2011-2014年共检出病原菌3072株。依次为肺炎克雷伯菌1644株（53.5%），大肠埃希菌947株（30.8%），铜绿假单胞菌481株（15.7%）。肺炎克雷伯菌、大肠埃希菌对亚胺培南的敏感率最高为100%，其次肺炎克雷伯菌对哌拉西林/他唑巴坦和丁胺卡那霉素的耐药率最低分别为8.2%和8.3%，大肠埃希菌对哌拉西林/他唑巴坦的耐药率最低为4.6%，。铜绿假单胞菌对丁胺卡那霉素和头孢匹美的耐药率最低为12.0%和12.2%。结论 临床应加强病原菌的监测，同时依据药敏结果，合理选择并规范使用抗菌药物，减少药源性疾病的发生率，预防和控制医院感染及多重耐药菌发生。 【关键词】抗菌药物；耐药性；病原菌；多重耐药菌 Abstract：OBJECTIVE To understand the permutations of gram negative bacilli clinical distribution and the changing trends in antimicrobial drug resistance in this hospital from January 2011 to December 2014 clinical isolates METHODS Clinical isolates of pathogenic bacteria by a review of analytical methods，VITEK2compact automatic bacterial analyzer identification of strains and drug sensitive test.RESULTS 3072 strains of pathogenic bacteria were detected in 2011-2014.Sequentially by Klebsiella pneumoniae 1644 strains（53.5%），Escherichia coli 947 strains（30.8%），481 strains of Pseudomonas aeruginosa（15.7%）.Pneumoniae，Klebsiella pneumoniae，Escherichia coli to imipenem sensitive rate highest was 100%，followed by Klebsiella pneumoniae to piperacillin piperacillin / tazobactam and butylamine card kanamycin resistance rate is the lowest were 8.2% and 8.3%，Escherichia coli to piperacillin / tazobactam resistant rate was 4.6%，the minimum.Pseudomonas aeruginosa kanamycin resistance and cefepime was the lowest of 12.0% and 12.2% of butylamine.CONCLUSION Clinicians should strengthen the monitoring of pathogens，at the same time according to the results of drug susceptibility，a reasonable choice of and regulate the use of antimicrobial agents，reduce the incidence of drug-induced diseases，prevention and control of hospital infection and multidrug resistant bacteria. Key words：Antibacterial drug；Drug resistance；Pathogenic bacteria；Multi drug resistant bacteria 随着抗菌药物的广泛应用以及各种侵入