Rubin s Pathology Clinicopathologic Foundations of Medicine (1) 461英文电子书.pdf

CHAPTER 10: BLOOD VESSELS | ATHEROSCLEROSIS 445 Table 10-4 EPIDEMIOLOGY: The major complications of ath- erosclerosis, including ischemic heart disease (coro- Atherogenesis nary artery disease), myocardial infarction, stroke and gangrene of the extremities, account for more than half of the annual mortality in the United States, with ischemic • Initiation and growth of fibroinflammatory lipid atheroma is a heart disease being the leading cause of death. The incidence slowly evolving dynamic process with superimposed acute of death from ischemic heart disease in Western countries events. peaked in the late 1960s, then declined by more than 30%. s • Risk factors accelerate progression. l There are wide geographic and racial variations in the inci- e s dence of ischemic heart disease and their progression to clin- s • The pathogenesis is multifactorial and thus the relative im