The Plasma Pharmacokinetics Of R Lipoic Acid Administered As Sodium R Lipoate To Healthy Human Subjects英文电子书.pdf
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Alternative Medicine Review Volume 12, Number 4 2007
Original
Research
The Plasma Pharmacokinetics
of R-(+)-Lipoic Acid Administered
as Sodium R-(+)-Lipoate to Healthy
Human Subjects.
David A. Carlson; Anthony R. Smith, PhD;
Sarah J. Fischer; Karyn L. Young; Lester Packer, PhD
curves were generated from spiking known concentrations of
RLA dissolved in ethanol and diluted in phosphate-buffered
Abstract saline (PBS) into each individual’s baseline plasma to account
BACKGROUND: The racemic mixture, RS-(+/-)-alpha-lipoic acid for inter-individual differences in protein binding and to prevent
(rac-LA) has been utilized clinically and in a variety of disease denaturing of plasma proteins. Plasma RLA content was
models. Rac-LA and the natural form, R-lipoic acid (RLA), determined by the percent recovery using high-performance
are widely available as nutritional supplements, marketed as liquid chromatography (electrochemical/coulometric detection)
antioxidants. Rac-LA sodium salt (NaLA) or rac-LA potassium (HPLC/ECD). RESULTS: As an
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