慢性乙型肝炎和慢性丙型肝炎用干扰素治疗出现罕见不良反应的病例报告.docVIP

精品论文 参考文献 慢性乙型肝炎和慢性丙型肝炎用干扰素治疗出现罕见不良反应的病例报告 胡西百合提王传国马燕 　　（新疆医科大学附属中医医院肝病科新疆乌鲁木齐830000） 　　【摘要】目的：观察alpha;-干扰素治疗慢性乙型肝炎（CHB）和慢性丙型肝炎（CBC）出现的罕见不良反应。方法：回顾性分析几例慢性乙型肝炎和慢性丙型肝炎用干扰素治疗出现罕见不良反应的病例报告。结果：本科观察2例患者均予以干扰素治疗后出现干咳之症，停药后缓解，考虑咳嗽与干扰素有关。长时间使用还很容易出现间质性肺炎症状和肝损害。患者个体因素、干扰素使用频度、用药剂量、治疗剂量与不良反应的严重程度和发生概率存在着极为重要的联系，因此，有效地处理好干扰素所带来的不良反应，能够提高患者治疗的依从性，保证患者可以较好地完成治疗。结论：为了有效地提高治疗的应答率，应该应用长疗程、大剂量的方法来治疗肝病，这样才能够最大程度地发挥出干扰素的最大疗效。通过预防性地使用药物和定期监测的方式来对患者的生活质量进行改善，提高患者治疗依从性，将干扰素不良反应所发生的程度和概率大大减少。 　　【关键词】慢性乙型肝炎；慢性丙型肝炎；不良反应；病例报告；alpha;-干扰素Chronic hepatitis b and chronic hepatitis c treatment with interferon in rare cases of adverse reactions report 　　HU Xi-bai-he-ti，WANG ZHuan-guo，MAYan(Liver diseases,traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University,Xinjiang Urumqi，830000) 　　【Abstract】Objective:To observe the effect of alpha; - interferon in treating chronic hepatitis B (CHB) and chronic hepatitis C (CBC) rare adverse reactions.Methods:A retrospective analysis of several cases of chronic hepatitis B and chronic hepatitis C treatment with interferon case report of rare adverse reactions.Results:2 patients were treated with undergraduate course of interferon after dry cough patients,after discontinuation of remission,considering about cough and interferon.It is very easy to appear interstitial pneumonia symptoms and liver damage in long time use.Individual patient factors,interferon use frequency,dosage,therapeutic dose and severity of adverse reactions and the probability of occurrence and there is a very important link,therefore,adverse reaction to deal effectively with interferon brings,can improve the patient compliance,ensure patients can complete the treatment.Conclusion:In order to effectively improve the therapeutic response rate,should be applied and long course,high doses to treat liver disease,so that it can exert the maximum effect of interferon.Through the use of prophylactic medication and regular monitoring of the way to the quality of life of patient