术后131I治疗对甲状腺乳头状癌患者血清P-Cadherin、CK-19和MMP-9影响的实验研究.docVIP

精品论文 参考文献 术后131I治疗对甲状腺乳头状癌患者血清P-Cadherin、CK-19和MMP-9影响的实验研究 杜映军 冷立军 　　(湖南省益阳市第一中医院 湖南益阳 413002) 　　【摘要】目的：探讨甲状腺乳头状癌患者血清P-钙粘蛋白(P-Cadherin)、细胞角蛋白-19(CK-19)和基质金属蛋白酶-9(MMP-9)的变化，以及甲状腺切除术后131I治疗对其的影响。方法：对50例甲状腺乳头状癌患者采用甲状腺全切术，术后1个月行131I核素治疗，1个月后测定患者治疗前后血清中P-Cadherin、CK-19和MMP-9水平。结果：甲状腺乳头状癌组血清P-Cadherin、CK-19和MMP-9水平较对照组显著升高(Plt;0.01)，且甲状腺乳头状癌伴淋巴结转移患者比无伴淋巴结转移患者血P-Cadherin、CK-19和MMP-9水平显著升高(均Plt;0.01)；甲状腺乳头状癌患者不伴淋巴结转移组和伴淋巴结转移组患者行甲状腺切除术后131I治疗后血清P-Cadherin、CK-19和MMP-9的含量较治疗前均降低(均Pgt;0.05)；且伴淋巴结转移组治疗后血清P-Cadherin、CK-19和MMP-9的含量较不伴淋巴结转移组降低更显著(均Plt;0.01)。结论：血清P-Cadherin、CK-19和MMP-9可能与甲状腺乳头状癌发生发展有关，甲状腺切除术后131I治疗能显著降低甲状腺乳头状癌患者P-Cadherin、CK-19和MMP-9水平，以期达到早期诊断早期防治的目的。 　　【关键词】甲状腺乳头状癌 P-钙粘蛋白 细胞角蛋白-19 基质金属蛋白酶-9 　　【中图分类号】R730.4 【文献标识码】A 【文章编号】1672-5085（2014）20-0007-03 　　The effects of 131I treatment after thyroidectomy on the serum P-Cadherin、CK-19 and MMP-9 in patients with thyroid papillary carcinoma 　　 patients 　　【Abstract】Objective：To explore the change of 131I treatment after thyroidectomy on thyroid papillary carcinoma patients and the impacts on the expressions of P-Cadherin、CK-19 and MMP-9. Methods: 50 cases of thyroid papillary carcinoma patients with thyroid full cut method, then 131 I nuclide therapy after1 months, the concentrations of P-Cadherin、CK-19 and MMP-9 in serum were detected before and after therapy.Results: The thyroid papillary carcinoma group serum P-Cadherin、CK-19 and MMP-9 levels were higher than the healthy control group(Plt;0.01); and he levels of serum P-Cadherin ,CK-19 and MMP-9 in papillary thyroid carcinoma with lymph node metastasis were significant higher than without lymph node metastasis(all Plt;0.01);The serum level of P-Cadherin ,CK-19 and MMP-9 on thyroid papillary carcinoma patients with lymph node metastasis and without lymph node metastasis after treatment were lower than those before treatment(Plt;0.01), moreover, the serum level of P-Cadherin ,CK-19 and MMP-9 on lymph node