uPAmRNA及其蛋白和uPAR、PAI1在宫颈癌中的表达及生物学意义.pdfVIP

中 文 摘 要 宫颈组织中的不同表达，总结其在宫颈鳞癌的发生发展及侵袭转移过程中的规律和对临 床的指导意义。方法采用原位杂交的方法在石蜡包埋组织分别检测30例正常宫颈， 型、有无淋巴转移方面进行对照分析比较其有无差异。结果 (1)LIPA、uPAR、PAI一1在NCE、CINICc组织的表达渐增强提示它们可能在宫颈癌发 能力、扩散范围、淋巴转移情况及预后估计等有一定的参考价值。 关键词宫颈肿瘤；m～；uPAR；PAJ一1；原位杂交；免疫组化 ABSTRACT To the 0fu∞妇ase activator objectiveinvestigateexpression tyI)ep】艇缸lirlogen (uF，A)、urokinase activator acti、限tor证一 typep1姗inogenrecept。r(“R幔)andpl姗inogen 0f thetisSue therole0fthesefactorsinthe bibitor(PAI一1)incervix，sunlup 0ccurrence， mcancerofthecervixandtheir fordimcal progreSSbn，mvasion s远mficance pmctice．Ⅳkth- of was in odsThe uPAmRNAdetectedsitu 30caseof expression by hybridizati。n(ISA)in nomlalcer访x caseofCINand68invasivecarcin()maof tiSSuede— tiSsue、30 o哪ix．aⅡthe tectedinthe cervicaItissue．TheIevelofthesetwofactorswere paraffin一锄beded o。mpared NCE、CIN、10C、variousclinical anddifferent a11d node arnong stageS patholcgictype lymph inv01vernem．R鹤ultrlomalceⅣical invasive 0f carcinoma (1)In tissueS，CINand cervix， the 0fuPAmRNA、uPA、uPARandPA卜1 anincr镪setrendthereissta— expreSsion appear tiStical nomalcervical a11dinvaSivecarcino眦of significanceanlong tiSsues、CIN cervix．(2) Ininvasivecarcinomaof of andPAI一1is