2013心律失常及心脏起搏新进展.pptx

2013心律失常及心脏起搏新进展深圳市孙逸仙心血管医院衣为民新型口服抗凝药物在房颤卒中预防领域中的应用直接凝血酶抑制剂 Ximelagatran已退市达比加群 RE-LY1-3直接Xa因子抑制剂利伐沙班 ROCKET-AF4阿哌沙班 ARISTOTLE5依度沙班 ENGAGE AF TIMI 486RELY、ROCKET AF 和ARISTOTLE研究均已完成1. Connolly et al, 2009; 2. Wallentin et al, 2009; 3. Oldgren et al, 2010; 4. Patel et al, 2010; 5. Lopez et al, 2010 6. NCdoxaban vs. Warfarin in Patients with AFENGAGE AF-TIMI 48 Clinical TrialsMethods randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk AFmedian follow-up, 2.8 years. The primary efficacy e