热疗辅助治疗宫颈癌疗效和安全性的系统评价.docVIP

精品论文 参考文献 热疗辅助治疗宫颈癌疗效和安全性的系统评价 邵阳市中医医院 湖南邵阳 422000 　　【摘 要】目的：系统评价热疗辅助放化疗在中晚期宫颈癌治疗中的疗效及安全性。方法：计算机检索TheCochraneLibrary（2015年第3期）以及PubMed、EMbase、CBM、VIP、CNKI和WanFangData数据库（检索时限均为从建库至2015年3月），纳入有关放化疗联合热疗治疗中晚期宫颈癌的文献。本研究共安排了2名评价员按照纳入与排除标准独立进行文献筛选、资料提取及质量评价后，采用RevMan5.3软件进行Meta分析。结果：共纳入9个随机对照试验（RCT）、669例患者。Meta分析结果显示：热疗辅助放化疗组的1年生存率明显高于放化疗组[OR=3.05，95%CI（1.70，6.68），P=0.005]、2年生存率[OR=2.29，95%CI（1.19，4.38），P=0.01]，治疗总有效率也明显高于放化疗组[OR=3.66，95%CI（2.31，5.81），P＜0.00001]，比较差异具有统计学意义，但2组在不良反应发生率中的差异比较无统计学意义。结论：热疗辅助放化疗的治疗方式显著提高了中晚期宫颈癌患者的近期和远期疗效。受纳入本研究的随机对照试验及患者的数量和质量的限制，这一结论还有待未来更多高质量的研究予以验证。 　　【关键词】宫颈癌；热疗；放疗联合化疗；Meta分析；系统评价；随机对照试验 　　Abstract：Objective：To evaluate the efficacy and safety of hyperthermia in the treatment of advanced cervical cancer. Methods：We searched TheCochraneLibrary（2015 third），PubMed，EMbase，CBM，VIP，CNKI and WanFangData（database were searched from inception to March 2015），the late chemotherapy combined with hyperthermia in the treatment of cervical cancer in literature. In this study，a total of 2 reviewers were included in this study，according to the inclusion and exclusion criteria independent of literature screening，data extraction and quality evaluation，the use of Meta software for RevMan5.3 analysis. Results：a total of 9 randomized controlled trials（RCT）and 669 patients were included. The results of Meta analysis showed that hyperthermia chemotherapy group 1 years survival rate was significantly higher than chemotherapy group [OR=3.05，95%CI（1.70，6.68），P=0.005]，the 2 year survival rate of [OR=2.29，95%CI（1.19，4.38），P=0.01]，the total efficiency of treatment was significantly higher than chemotherapy group（2.31 [OR=3.66，95% CI，5.81），P lt; 0.00001]，there were statistically significant differences between the 2 groups，but the adverse reaction rate in difference was not statistically significant. Conclusion：the treatment of adjuvant radiotherapy and chemotherapy significantly improves the short-term and long-term efficacy of patients with advanced cervical canc