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International Journal of Pharmaceutics 400 (2010) 86–95
Contents lists available at ScienceDirect
International Journal of Pharmaceutics
j o u rn al h omepage: w w w. elsev /locate/ijpharm
Synergistic effects between natural histone mixtures and polyethylenimine
in non-viral gene delivery in vitro
Anne Schneeweiss a , Kevin Buyens b , Matthias Giese a , Niek Sanders c , Sebastian Ulbert a,∗
a Vaccine Development Unit, Fraunhofer Institute for Cell Therapy and Immunology, Perlickstrasse 1, 04103 Leipzig, Germany
b Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Gent, Belgium
c Laboratory of Gene Therapy, Faculty of Veterinary Sciences, Ghent University, Heidestraat 19, 9820 Merelbeke, Belgium
a r t i c l e i n f o a b s t r a c t
Article history: Nanoparticles made of plasmid DNA (pDNA) and cationic polymers are promising strategies for non-viral
Received 7 May 2010 gene delivery. However, many cationic polymers are toxic to cells when used in higher concentrations.
Received in revised form 18 August 2010 Positively charged proteins, such as histones, are biodegradable and a good alternative, especially for
Accepted 25 August 2010
potential in vivo applications. It has previously been shown that histones are able to complex DNA and
Available online 9 September 2010
mediate transfection of cells. To investigate possible synergistic effects between the different histone
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