米非司酮治疗难治性功能失调性子宫出血的临床探讨.docVIP

精品论文 参考文献 米非司酮治疗难治性功能失调性子宫出血的临床探讨 王福兰 　　（四川省平昌县人民医院 四川平昌 646400） 　　【摘要】目的：分析探讨临床难治性功能失调性子宫出血的病因，观察米非司酮治疗难治性功能失调性子宫出血的临床效果。方法：回顾性分析2013年1月～2015年1月我院收治的56例难治性功能失调性子宫出血患者的临床资料，对其患者采用口服米非司酮，连续服用3个月为1个疗程，症状改善不良者可再重复1个疗程的治疗。观察月经情况、内膜厚度、激素水平及不良药物反应。结果：所有患者治疗期间均获得有效止血，疗效显著54例，无效2例，总有效率96.4%。治疗前后子宫内膜厚度相比，差异有统计学意义（Plt;0.05）；治疗后FSH、LH、P、E2水平较治疗前明显下降（均Plt;0.05）。结论：米非司酮治疗难治性功能失调性子宫出血，止血迅速，疗效显著，复发率低，不良反应轻微，可以较好地应用于临床。 　　【关键词】米非司酮；难治性功能失调性子宫出血；治疗；疗效 　　【中图分类号】R453 【文献标识码】A 【文章编号】1007-8231（2015）03-0011-03 　　Clinical study of mifepristone in the treatment of intractable dysfunctional uterine bleeding Wang Fulan 　　Sichuan Pingchang Peoples Hospital 646400,China 　　【Abstract】Objective To investigate the clinical effect of mifepristone in the treatment of intractable dysfunctional uterine bleeding. Methods The clinical data of 56 patients with intractable dysfunctional uterine bleeding treated in our hospital from January 2013 to January 2015 were retrospectively analyzed. The patients were treated with oral administration of mifepristone for 3 months and 1 months of treatment. Observe the menstrual conditions, endometrial thickness, hormone levels and adverse drug reactions. Results All patients were treated with effective hemostasis, 54 cases were effective, 2 cases ineffective, the total effective rate was 96.4%. Before and after treatment, the endometrial thickness was significantly different (Plt;0.05); the level of FSH, P, LH and E2 after treatment was significantly decreased (Plt;0.05). Conclusion Mifepristone in the treatment of intractable dysfunctional uterine bleeding, bleeding quickly, curative effect is obvious, the recurrence rate is low, the adverse reactions are mild, can be better applied to clinical. 　　【Key words】Mifepristone; Refractory dysfunctional uterine bleeding; Treatment; Efficacy 　　功能失调性子宫出血（简称功血）是指神经内分泌的调节功能失常而非生殖器官本身的器质性病灶或全身疾病所引起的不正常子宫出血，多发生在中年妇女，多是由于中年妇女卵巢功能逐渐减退，对促性腺激素的反应下降所致。患者有不同程度的月经过多、月经周期缩短、经期延长、不同程度的感染、贫血甚至休克，严重影响劳动能力及患者的生活质