内质网应激在胰岛素抵抗中的作用-中国细胞生物学学报.pdfVIP

中国细胞生物学学报 Chinese Journal of Cell Biology 2016, 38(1): 91–97 DOI: 10.11844/cjcb.2016.01.0314 内质网应激在胰岛素抵抗中的作用 * * 何人可 胡越皓 张嘉平 樊秋菊 蔡 蓉 (上海交通大学医学院, 生物化学与分子细胞生物学系, 上海 200025) 摘要 2型糖尿病正成为日益突出的世界性健康问题。胰岛素抵抗在2型糖尿病的发病中起 到了重要的促进作用。近年来, 很多研究发现, 内质网应激与胰岛素抵抗具有密切的联系。内质网 报 应激不仅是胰岛素信号通路的直接负调节因素, 还可通过多种方式作用于不同靶组织促进胰岛素 抵抗。该文就内质网应激与胰岛素抵抗在2型糖尿病发病中的作用机制及可能的靶向治疗策略作 一综述。 关键词 内质网应激; 胰岛素抵抗; 未折叠蛋白质反应; 靶向治疗 学 The Role of Endoplasmic Reticulum Stress in Insulin Resistance 学 He Renke, Hu Yuehao, Zhang Jiaping, Fan Qiuju*, Cai Rong* (Department of Biochemistry Molecular Cell Biology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China) Abstract Type 2 diabetes mellitus (T2DM) is increasingly becoming a prominent global health problem. 物 Insulin resistance (IR) plays an important role in promoting the development of T2DM. In recent years, a bunch of studies find that the endoplasmic reticulum stress (ER stress) and IR are inseparable. ER stress acts not only as the direct negative regulatory factor in the insulin signaling pathway, but also targets different tissues in various ways to enhance systemic insulin resistance. In this review, we will give a brief review about the molecular mechanism of 生 ER stress and IR in the occurrence and development of T2DM, as well as the possible targeted therapeutic strategy toward it. Keywords endoplasmic reticulum stress; insulin resistance; unfolded protein reaction; targeted therapy 胞 内质网应激(endoplasmic reticulum stress, ER UPR) 。自2004年Hota