精神分裂症患者血清神经生长相关蛋白测定的意义.docVIP

精品论文 参考文献 精神分裂症患者血清神经生长相关蛋白测定的意义 1山东省东营市胜利医院检验科 山东 东营257055 2山东省东营市胜利医院精神卫生康复中心 山东 东营257055 【摘要】 目的 检测精神分裂症患者血清神经生长相关蛋白水平，并探讨其与精神病理症状的关系。方法 采用酶联免疫分析法检测91例精神分裂症患者(患者组)和59例健康正常人(对照组)的血清GAP-43水平，结合阳性和阴性症状量表(PANSS)总分及各因子分进行相关分析。结果 患者组血清GAP-43水平(1.13plusmn;0.65mu;g/L)低于对照组(1.92plusmn;0.78mu;g/L)(Plt;0.01)，其中低神经生长相关蛋白血症(LGAP-43lt;0.5mu;g/L)的发生率明显高于对照组(chi;2=13.2，Plt;0.05)。GAP-43水平与PANSS总分及阴性症状总分呈负相关(r=-0.47/-0.44，Plt;0.05)。结论 精神分裂症患者血清GAP-43水平的降低与精神病理症状(特别是阴性症状)有关，与精神分裂症性别及年龄无关(Pgt;0.05)。 【关键词】 精神分裂症；神经生长相关蛋白；酶联免疫分析 Determination meaning of blood serum Growth Associated Protein Level in episode Schizophrenia. Hanlaixin, Dengkuanguo,Yinshihua, et al. ShengLi Hospital, Dongying Shandong 257055 【Abstract】 Objective To observe blood serum Growth Associated Protein level of episode schizophrenia and explore the correlation between blood serum Growth Associated Protein level and psychopathic symptom. Methods The blood serum Growth Associated Protein 43 level was measured by enzyme-linked immunosorbent assay in case-control study including 91 episode schizophrenic patients and 59 healthy controls, and the correlation between the blood serum Growth Associated Protein level and PANSS score were explored. Results The blood serum GAP-43 level (1.13plusmn;0.65mu;g/L) was significantly lower in patients group than that of the control (1.92plusmn;0.78mu;g/L,Plt;0.01). The case with lower Growth Associated Protein 43 was much more in patients group than that in the control (chi;2=13.2,Plt;0.05). The blood serum Growth Associated Protein level positively correlated to the PANSS total score and the negative symptom total score. Conclusion The blood serum GAP-43 level of lower in episode schizophrenia patients was related with psychopathic symptom, has nothing to do with episode schizophrenia gender and age. 【Key words】 episode schizophrenia； Growth Associated Protein；enzyme-linked immunosorbent assay 【中图分类号】R749.3【文献标识码】A【文章编号】1001-5213(2016)09-0204-01 精神分裂症是一种患病率高，容