类黄酮抗氧化作用研究进展精选.pdfVIP

Chinese Journal of New Drugs 2004, Vol1 13 No1 12 2004 13 12 [ 30] Liu H C, Zhang XJ, Yang YY, e t al1 T he stereoselectivity in ( 1) B 83-861 r enal clearance of tr ans-tramadol and its active m eta olite, t rans-O-dem ethyltramadol[ J] 1 A c ta Phar macol Sin1 2002, 23 ( 收稿日期: 2004-06- 07) 1 2 2 2 , , , ( 1 浙江省丽水学院化学系, 丽水323000; 2 东华理工学院应用化学系, 江西抚州344000) [ ] 类黄酮摄入量和心血 疾病发病率成反比可能与脂蛋白与黄酮类抑制低密度脂蛋白氧化作用巨噬 细胞形成和动脉粥样硬化有关黄酮类对动脉低密度脂蛋白细胞间接氧化作用已通过对其在脂蛋白动脉的细胞 累积而被测定黄酮类可以通过清除反应的氧氮种类, 螯合金属离子和节制低密度脂蛋白联合抗氧化作用减少 低密度脂蛋白氧化作用通过抑制细胞氧合酶( 如烟酰胺腺嘌呤二核苷酸磷酸盐, 减少氧化酶的形成) 或通过 启动细胞抗氧化剂( 如谷胱甘肽系统) 也能减少巨噬细胞氧化压力 [ ] 黄酮; 低密度脂蛋白; 动脉粥样硬化 [ ] R5431 15; R363 [ ] A [ ] 1003-3734( 2004) 12- 1238-06 Advance of flavonoids antioxidation 1 2 2 2 XIAO Kun-fu , LIAO Xiao-feng , YU Rong , LIAN G Hua-zheng ( 1D ep artment of Chemistry , L ishui College, L ishui Zhej iang 323000, China 2 D ep ar tm ent of Chemistry , D onghua College of Technology , F u hou 344000, China) [ Abstract] T he diet rich in flavonoids may e attri uted to few er incidences of cardiovascu- lar diseases, w hich act y inhi iting LDL oxidation, macrophage cells formation and atherosclero- sis. T he effects of flavonoids on arterial cel-l mediated oxidation of LDL may e measured y accu- mulation of lipoproteins in arterial cells, such as macrophages. Flavonoids reduce the LDL perox- idation y scavenging reactive oxygen/ nitrogen species, chelation of transition metal ions and de- creasing LDL-associated antioxidative functions. Fl