联合检测缺血修饰白蛋白和同型半胱氨酸对冠状动脉硬化性心脏病辅助诊断的临床价值分析.docVIP

精品论文 参考文献 联合检测缺血修饰白蛋白和同型半胱氨酸对冠状动脉硬化性心脏病辅助诊断的临床价值分析 段敏 　　（乡城县疾控中心 四川 甘孜 627850） 　　【摘要】 目的：探讨联合检测缺血修饰白蛋白和同型半胱氨酸对冠状动脉硬化性心脏病辅助诊断的临床价值。方法：实验组由选择2013年3月至2014 年5月确诊为冠状动脉硬化性心脏病的79例患者组成，对照组由80例同期健康体检者组成，对所有纳入对象的血清同时检测缺血修饰白蛋白和同型半胱氨酸的浓度水平，综合统计分析结果。结果：实验组患者的缺血修饰白蛋白和同型半胱氨酸浓度水平均明显高于对照组（p＜0.05），差异具有统计学意义。阳性率分析可见，患者单独检测缺血修饰白蛋白和同型半胱氨酸的阳性检出率分别为86.1%和88.6%，联合两项指标检测的阳性检出率为96.2%，单项检测分别与联合检测阳性率结果两两比较，差异具有统计学意义（p＜0.05）。以临床诊断结果为金标准，联合两项检测结果与临床诊断结果Kappa一致性分析结果为0.96。结论：缺血修饰白蛋白和同型半胱氨酸都是辅助诊断冠状动脉硬化性心脏病疾病的有效指标，联合两项指标检测可以有效提高阳性检出率，降低漏诊率，适用于疾病的筛查，值得推广。 　　【关键词】 冠状动脉硬化性心脏病；缺血修饰白蛋白；同型半胱氨酸 　　【中图分类号】R541 【文献标识码】A 【文章编号】2095-1752（2015）17-0015-02 　　To analyse the clinical significance of the Coronary arteriosclerotic heart disease aided diagnosis by the Ischemia Modified Albumin and Homocysteine joint detection Duan Min. The Centers for Disease Control and Prevention of the Xiangcheng County, Sichuan Province, Ganzi Tibetan Autonomous Prefecture 627850,China 　　【Abstract】Objective To analyse the clinical significance of the coronary arteriosclerotic heart disease aided diagnosis by the Ischemia Modified Albumin(IMA) and Hcy(Hcy) joint detection. Methods Choosing 79 cases of patients with coronary arteriosclerotic heart disease for the study group, and choosing 80 cases healthy check-up for the control group, testing the IMA and Hcy, analyze the results comprehensively. Results Compared with the control group, there were significantly higher of the study group of the IMA and Hcy results（p＜0.05). The positive rate of the IMA and Hcy was 86.1% and 88.6%, combined with two indicators detection positive rate was 96.2%, there were significantly difference between the separate and combined detection result（p＜0.05). Clinical diagnosis as the gold standard, the Kappa of the combined with two indicators detection was 0.96. Conclusion IMA and Hcy are effective in diagnosis of coronary heart disease, combined detection of two indexes can improve the positive detection