灵芝多糖对小鼠糖耐量的影响研究.pdf

China MycologicalSocietyof First on MedicinalIndustry DevelopmentofChinas Fungi ProceedingsoftheSymposium 灵芝罗糖对小鼠糖耐量的景乏响 He Min，Wu Feng，XuJi—liang 何敏，吴锋，徐济良 (南通大学医学院药理学教研室，南通226001) of Medical 226001 Departmentpharmacology，NantongCollege，Nantong Effects Lucidum onthe ofGanoderma toleranceinmice Polysaccharidesglucose 摘要 目的：初步探讨灵芝多糖对正常和糖尿病小鼠糖耐量的影响。方法：采用腹腔注 灵芝多糖后，正常和糖尿病小鼠糖N-量的改变。结果：灵芝多糖0．59／kg仅能显著降低 h和2h血 糖尿病小鼠餐后1h和2n血糖，而灵芝多糖1．59／kg对正常和糖尿病小鼠餐后1 糖均有显著降低作用。结论：灵芝多糖能改善正常和四氧嘧啶糖尿病小鼠糖耐量。 关键词 灵芝多糖；糖尿病；血糖；小鼠 Abstract theeffectsofGanodermaLucidum the 0bjective：To investigate toleranceinnormalanddiabetic glucose mice．Methods：DiabeticmicemodelwasinducedAlloxan by ordiabeticmicewere a doseofGLPs the (200mg／kg，ig．)．Normal givensingle 0．5，1．59／kgig．and by of tolerancewereobserved could lower changesglucose respectively．Results：GLPs0．59／kg significantly theserum levelsatlhand2hafter administrationindiabetic glucose glucose mice．However，GLPs 1．59／ has effectsonserum levelsatlhand2hi