执业药师[认证考试资料].pptxVIP

The Analysis of Steroid Hormone Drugs;The main contents： ;Fundamental requirement: ;Analysis;基本结构与分类;General structures;Sort;Galair anabolic hormones;Hydrocortisone Acetate;Nandrolone Phenylpropionate 苯丙酸诺龙;Norethisterone 炔诺酮;鉴 别 实 验;Identification tests;鉴 别 实 验;Identification tests;Names ;Ultraviolet spectrophotometry;The UV spectra of hydrocotisone and betamethasone;;Melting points of derivatives;Melting point of derivatives;Melting points of derivatives;Infrared spectrophotometry;–C–OH (alcohol ) everywhere 1230~1000 ;υC=C1615，1590，1505cm－1苯环的骨架振动； υ≡CH 3300cm－1 炔的特征峰； υ－OH 3610cm－1游离酚羟基的伸缩振动； υ－OH 3505cm－1 C17- 羟基的伸缩振动。;IR spectrum of Dexamethasone(地塞米松);Infrared spectrophotometry;; The intensity with which a bond absorbs radiation depends on its dipole moment. The order of intensity of absorption is: C–O C– Cl C –N C– C–OH C–C–H The intensity depends on the relative electronegativity of the atoms involved in the bond. The intensity of the stretching of carbon-carbon double bonds is increased when they are conjugated to a polar double bond. The order of intensity is : C=C–C=O C=C–C=C C=C–C–; Two types of instrument are commonly used for obtaining IR spectra: dispersive instruments which use a monochromator to select each wavenumber in turn in order to monitor its intensity after the radiation has passed through the sample and Fourier transform instruments that use an interferometer. ;;;A qualitative fingerprint check for the identity of raw material used in manufacture and for identifying drugs. Used in synthetic chemistry as a preliminary check for compound identity particularly for the presence or absence of a carbonyl group, which is difficult to check by any other method. Can be used to characterize samples in the solid and semi-solid states such as creams and tablets. ;Used as a fingerprint test for films, coatings