胆囊癌与胆囊结石的临床相关性分析.docVIP

精品论文 参考文献 胆囊癌与胆囊结石的临床相关性分析 袁锋 　　（成都铁路分局医院外一科 四川 成都 610081） 　　【摘要】 目的：探讨胆囊结石与胆囊癌发生及其进展的关系。方法：对经病理证实的55例胆囊癌进行回顾性分析。结果：55例胆囊癌中，无结石组占38%，结石组占62%，其中单发结石组占16%，多发结石组占45%；无结石组、单发结石组、多发结石组的胆囊癌TNM Ⅳ期所占百分比分别为43%、67%、72%，结石组与无结石组比较、多发结石组与无结石组比较均具有显著性差异（P﹤0.05），单发结石组因数量较少，其与无结石组比较没有统计学意义。结论：胆囊结石尤其是胆囊多发结石是胆囊癌发生的危险因素；伴胆囊结石的胆囊癌较不伴胆囊结石的胆囊癌浸润、转移明显。 　　【关键词】 胆囊癌；胆囊结石；进展；发生 　　【中图分类号】R657.4 【文献标识码】A 【文章编号】2095-1752（2015）19-0040-02 　　 　　Clinical correlation analysis of gallbladder carcinoma with gallstones 　　【Abstract】Objective To explore the relationship between gallstones and the generation of gallbladder carcinoma, and the relationship between gallstones and the progress of gallbladder carcinoma. Methods A retrospective clinical anal-ysis was made in 55 cases of gallbladder carcinoma which were diagnosed. Results The percentages of gallbladder carcinoma without gallstones, gallbladder carcinoma with gallstones, gallbladder carcinoma with single gallstone and gallbladder carcinoma with multiple gallstones were 38%, 62%, 16%, 45% respectively. And the percentages of TNM stage Ⅳ in the groups were 43%, 71%, 67%, 72% respectively. There were significant differences among the groups. However, the differ-ences between gallbladder carcinoma with single gallstone and gallbladder carcinoma without gallstones have not been confir-med. Conclusions Gallstones, especially multiple gallstones, is closely correlated with the generation of gallbladder carcinoma. At the same time, the infiltration and metastasis of gallbladder carcinoma with gallstones are more obvious than that without gallstones. 　　【Key words】Gallbladder carcinoma；Gallstones；Progress；Generation 　　胆囊癌是胆道系统最常见的恶性肿瘤，早期诊断困难，预后差。胆囊结石是胆囊癌的高危因素[1]。目前，国内外关于胆囊结石与胆囊癌发生的研究较多，关于胆囊结石与胆囊癌进展的研究较少。本研究就55例胆囊癌对胆囊结石与胆囊癌发生的关系进行了进一步分析，并重点探讨了胆囊结石与胆囊癌进展的关系。 　　1.临床资料 　　1.1 一般资料 　　男性12例，女性43例，30岁以下1例，30岁～40岁3例，41岁～50岁8例，51岁～60岁11例，60岁以上32例。伴胆囊结石者34例，有明确胆囊结石病史者8例（最长20年，最短1年）,不伴胆囊结石者21例。意外胆囊癌22例，其中伴胆囊结石者15例，不伴胆囊结石者7例